| Protein Name: | Glucosamine--fructose-6-phosphate aminotransferase (Q06210) |
|---|---|
| Gene Name: | GFPT1 |
| Description: | Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2 6 1 16) (Hexosephosphate aminotransferase 1) (D-fructose-6- phosphate amidotransferase 1) (GFAT 1) (GFAT1) |
| PDB ID: | 2V4M |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Gabapentin | Diabetic Kidney Disease | Increased flux through the hexosamine biosynthetic pathway with glutamine:fructose-6-phosphate-amidotransferase (GFAT) as rate-limiting enzyme has been linked to the enhanced bioactivity of the prosclerotic cytokine transforming growth factor beta1 (TGF-beta1) in fibrotic complications@ particularly in diabetic kidney disease. [ ADR Type 2 ] | Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts |
| Glutamine | Apoptosis | Increased flux through the hexosamine biosynthetic pathway with glutamine:fructose-6-phosphate-amidotransferase (GFAT) as rate-limiting enzyme has been linked to the enhanced bioactivity of the prosclerotic cytokine transforming growth factor beta1 (TGF-beta1) in fibrotic complications@ particularly in diabetic kidney disease. [ ADR Type ] | Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts |
| Glutamine | Arrest Cellular Proliferation | GFAT gene underGOes a late transcriptional response to EGF@which arrest cellular proliferation [ ADR Type 3 ] | Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose |
This panel provides information on drug category
| Toxicity | Source |
|---|