| Protein Name: | Eukaryotic translation initiation factor 4E (P06730) |
|---|---|
| Gene Name: | EIF4E |
| Description: | Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) |
| PDB ID: | 1IPB |
| Protein Family: | |
| Protein Category: | Nuclear Protein |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Impairs Insulin | EtOH altered the distribution of eukaryotic initiation factor (eIF)4E@ as evidenced by a decreased amount of active eIF4E. eIF4G complex@ an increased amount of inactive eIF4E-binding protein (BP)1 complex@ and decreased 4E-BP1 phosphorylation@which impairs insulin and IGF-I stimulation of S6K1. [ ADR Type 2 ] | Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle |
This panel provides information on drug category
| Toxicity | Source |
|---|