| Protein Name: | DNA topoisomerase 2-alpha (P11388) |
|---|---|
| Gene Name: | TOP2A |
| Description: | |
| PDB ID: | 1LWZ |
| Protein Family: | PF00204, PS00177 |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Etoposide | Apoptosis | Induction of apoptosis by etoposide and related inhibitors of topoisomerase II is mediated through a cell death pathway that does not require SAPK-dependent recruitment of AP1 [ ADR Type 2 ] | Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation |
| Teniposide | Cytotoxicity | Teniposide [4#-demethylepipophyllotoxin-4-(4@6-O-thenylidene-beta-D- glucopyranoside) (VM-26)] is a cancer chemotherapeutic drug with a high target specificity for DNA topoisomerase II@This agent INDUCES repairable protein-bridged double-strand DNA breaks@ which have been correlated with cytotoxicity@ but high concentrations of VM-26 also INDUCE irreversible DNA degradation and apoptotic cell death. [ ADR Type 3 ] | Teniposide induces nuclear but not mitochondrial DNA degradation |
This panel provides information on drug category