| Protein Name: | Cytochrome c oxidase (P00395) |
|---|---|
| Gene Name: | MT-CO1 |
| Description: | Cytochrome c oxidase subunit 1 (EC 1 9 3 1) (Cytochrome c oxidase polypeptide I) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Transporters |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Carbachol | Acth | The involvement of prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH. [ ADR Type 1 ] | Effect of constitutive- and inducible-cyclooxygenase in the carbachol-induced pituitary-adrenocortical response during social stress |
| Zalcitabine | Cardiac Malfunctions | ddC treatment provoked a surprisingly rapid appearance of cardiac malfunctions characterized by significantly decreased activity of respiratory complexes (NADH: cytochrome c oxidoreductase and cytochrome oxidase) [ ADR Type 2 ] | Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions |
| Zidovudine | Mitochondrial Defects | A significant decrease in CYTOX activity in heart and RG was evident,indicate that AZT induces mitochondrial defects primarily in muscles with the highest oxidative capacities (heart and RG) [ ADR Type 2 ] | Zidovudine (AZT) induced alterations in mitochondrial biogenesis in rat striated muscles |
This panel provides information on drug category
| Toxicity | Source |
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