| Protein Name: | CYP1A (P04798) |
|---|---|
| Gene Name: | CYP1A1 |
| Description: | Cytochrome P450 1A1 (EC 1 14 14 1) (CYPIA1) (P450-P1) (P450 form 6) (P450-C) |
| PDB ID: | 4I8V |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Flutamide | Hepatotoxicity | Flutamide is toxic to rat hepatocytes as a result of the cytochrome P450 (3A and also 1A)-mediated formation of electrophilic metabolites@ whose damaging effects are further aggravated by the inhibitory effect of flutamide on mitochondrial respiration and ATP formation | |
| Propranolol | Carcinogenicity | Propranolol may lead to complications in drug therapy and modulate the toxicity or carcinogenicity of drugs that are substrates for the CYP1A1(reserpine) [ ADR Type 4 ] | Pharmacological analysis of the mechanisms involved in the tachycardic and vasopressor responses to the antimigraine agent, isometheptene, in pithed rats |
This panel provides information on drug category
| Toxicity | Source |
|---|