| Protein Name: | Beta-glucuronidase (P08236) |
|---|---|
| Gene Name: | GUSB |
| Description: | Beta-glucuronidase precursor (EC 3 2 1 31) (Beta-G1) |
| PDB ID: | 1BHG |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hepatotoxin-Induced Effects | Acetaminophen markedly decreased biliary concentrations and efflux rates of beta-NAG and beta-GLUC in Fischer-344 rats@suggesting that the hepatotoxin-induced effects on biliary iron excretion may be mediated through effects on lysosomal exocytosis. [ ADR Type 2 ] | Biliary excretion of lysosomal enzymes, iron, and oxidized protein in Fischer-344 and Sprague-Dawley rats and the effects of diquat and acetaminophen |
| Captopril | Leukopenia | Granulocyte aggregation was shown by the turbidimetric method and cellular activation was confirmed by the release of the granule associated enzyme lysozyme and beta-glucuronidase@which possibly mediated mechanism of peripheral leukopenia [ ADR Type 1 ] | A Captopril-induced granulocyte aggregation A possible complement mediated mechanism of peripheral leukopenia |
This panel provides information on drug category
| Toxicity | Source |
|---|