| Protein Name: | Baculoviral IAP repeat-containing protein (Q13490) |
|---|---|
| Gene Name: | BIRC2 |
| Description: | Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B) |
| PDB ID: | 1QBH |
| Protein Family: | |
| Protein Category: | Auxiliary transport protein | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Paclitaxel | Apoptosis | Paclitaxel-induced apoptosis of breast cancer cells Constitutive activation of NF-kappaB leads to overexpression of the anti-apoptotic genes c-inhibitor of apoptosis 2 (c-IAP2) and manganese superoxide dismutase (Mn-SOD) in breast cancer cells [ ADR Type 2 ] | Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor |
This panel provides information on drug category
| Toxicity | Source |
|---|