| Protein Name: | Alanine aminotransferase (P24298) |
|---|---|
| Gene Name: | GPT |
| Description: | Alanine aminotransferase (EC 2 6 1 2) (Glutamic--pyruvic transaminase) (GPT) (Glutamic--alanine transaminase) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hepatotoxicity | Acetaminophen-induced hepatotoxicity [ ADR Type 1 ] | Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice |
| Ciprofloxacin | Fulminant Hepatic Failure | Serum aspartate aminotransferase and Alanine aminotransferase concentrations were markedly elevated@which leads to Fulminant hepatic failure [ ADR Type 2 ] | Fulminant hepatic failure possibly related to ciprofloxacin |
| Ciprofloxacin | Haematological Toxicity | Usually invariably reversible elevations of serum aminotransferases@which leads to significant haematological or biochemical toxicity [ ADR Type 1 ] | Ciprofloxacin: an overview of adverse experiences J Antimicrob |
| Cocaine | Hepatic Injury | In the case of cocaine@ adrenergic antaGOnist cotreatment was capable of reducing serum alanine aminotransferase activities by approximately 50%@creating the potential for increased susceptibility to hepatic injury [ ADR Type 1 ] | Adrenergic modulation of hepatotoxicity |
| Erythromycin | Adverse Gastrointestinal Effects | Adverse gastrointestinal effects [ ADR Type 1 ] | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis |
| Furazolidone | Loss Of Appetite | Increase in serum aspartate aminotransferase (AST)@ Alanine aminotransferase (ALT) and alkaline phosphatase and a decrease in serum total protein@which leads to a loss of appetite causing emaciation followed by nervous disturbances (compulsive movements and circling) [ ADR Type 1 ] | Toxicological and biological studies on Japanese quails fed graded levels of furazolidone |
| Halothane | Hepatotoxicity | Increases in serum enzyme activities of the alanine aminotransferase (GPT) and the sorbitol dehydrogenase (SDH) were evident immediately following exposure and were six-fold higher@which leads to halothane hepatotoxicity [ ADR Type 2 ] | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model |
| Halothane | Liver Cell Necrosisand Mitoses | Focal liver cell necrosisand occasional mitoses [ ADR Type 2 ] | Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure |
| Halothane | Liver Cells Fatty Change | Many liver cells showed fatty change. [ ADR Type 2 ] | Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure |
| Halothane | Lobular Disarray | Considerable lobular disarray [ ADR Type 2 ] | Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure |
| Halothane | Porcine Stress Syndrome | Serum alanine aminotransferase increased in only those animals sacrificed at 24 hrs@ which leads to halothane induced porcine stress syndrome [ ADR Type 1 ] | Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation |
| Isoniazid | Hepatotoxicity | Isoniazid-rifampin elevates of the serum alanine aminotransferase (ALT) concentration (greater than 100 units)@which leads to hepatotoxic reactions. [ ADR Type 4 ] | Hepatotoxic reactions in children with severe tuberculosis treated with isoniazid-rifampin |
| Lovastatin | Hepatotoxicity | Depletion of a nonsterol metabolite(s) of mevalonate critical for cell viability@which leads to lovastatin-induced hepatotoxicity. [ ADR Type 2 ] | Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits |
| Phenytoin | Hyperbilirubinemia | Increased activities of Alanine aminotransferase@ alkaline phosphatase (AP)@ and gamma-glutamyltransferase@leading to clinical jaundice and developed hyperbilirubinemia@ delayed sulfobromophthalein excretion@ and increased conjugated bile acid concentrations. [ ADR Type 1 ] | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis |
| Primidone | Hhepatic Cirrhosis | Hepatic cirrhosis [ ADR Type 2 ] | Hepatic cirrhosis associated with long-term primidone therapy in a dog |
| Primidone | Hyperbilirubinemia | Increased activities of Alanine aminotransferase@ alkaline phosphatase (AP)@ and gamma-glutamyltransferase@leading to clinical jaundice and developed hyperbilirubinemia@ delayed sulfobromophthalein excretion@ and increased conjugated bile acid concentrations. [ ADR Type 1 ] | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis |
| rosaramicin | Adverse Gastrointestinal Effects | Adverse gastrointestinal effects [ ADR Type 1 ] | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis |
| Sodium Lactate | Alkalosis | Depression of 40% in the renal uptake of glutamine with a 38% decrease in renal ammoniagenesis@leading to sodium lactate alkalosis. [ ADR Type 1 ] | The metabolic response of the kidney to acute sodium lactate alkalosis |
| Theophylline | Metabolic Acidosis | Metabolic acidosis [ ADR Type 2 ] | Massive theophylline overdose with atypical metabolic abnormalities |
This panel provides information on drug category
| Toxicity | Source |
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