| Protein Name: | Adenylate cyclase (Q08828) |
|---|---|
| Gene Name: | ADCY1 |
| Description: | Adenylate cyclase type 1 (EC 4 6 1 1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Fentanyl | Development Of Tolerance | Three-hour pretreatment of mu receptors with fentanyl and its analogs desensitized the mu receptor by uncoupling it from adenylyl cyclase@indicating that desensitization of the mu receptor may be a molecular basis for the development of tolerance to fentanyl and its analogs [ ADR Type 1 ] | Fentanyl and its analogs desensitize the cloned mu opioid receptor |
| Reserpine | Ulcer | Before the appearance of reserpine ulcer@ significant changes in the feedback mechanism system@ i e between the ATP--membrane ATPase--ADP and the ATP--adenylate cyclase--cAMP energy systems@ can be observed in the rat gastric fundal mucosa [ ADR Type 2 ] | Cellular energy systems and reserpine ulcer in rats |
This panel provides information on drug category
| Toxicity | Source |
|---|