| Drug Name: | moclobemide (71320-77-9) |
|---|---|
| PubChem ID: | 4235 |
| SMILES: | C1COCCN1CCNC(=O)C2=CC=C(C=C2)Cl |
| InchiKey: | YHXISWVBGDMDLQ-UHFFFAOYSA-N |
| Therapeutic Category: | Antidepressive Agents, Central Nervous System Agents, Enzyme Inhibitors, Monoamine Oxidase Inhibitors, Psychotropic Drugs |
| Molecular Weight (dalton) | : | 268.744 |
| LogP | : | 1.402 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 41.57 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Rizatriptan (145202-66-0) | Dizziness | Synergistic | MAO-A is the principal enzyme concerned with the metabolism of rizatriptan. Moclobemide inhibits this enzyme and therefore raises rizatriptan levels | The effects of moclobemide on the pharmacokinetics of the 5-HT1B/1D agonist rizatriptan in healthy volunteers |
| Rizatriptan (145202-66-0) | Nausea | Synergistic | MAO-A is the principal enzyme concerned with the metabolism of rizatriptan. Moclobemide inhibits this enzyme and therefore raises rizatriptan levels | The effects of moclobemide on the pharmacokinetics of the 5-HT1B/1D agonist rizatriptan in healthy volunteers |
| Rizatriptan (145202-66-0) | Somnolence | Synergistic | MAO-A is the principal enzyme concerned with the metabolism of rizatriptan. Moclobemide inhibits this enzyme and therefore raises rizatriptan levels | The effects of moclobemide on the pharmacokinetics of the 5-HT1B/1D agonist rizatriptan in healthy volunteers |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category