InAADR

Drug Information

Drug Name: Zonisamide (68291-97-4)
PubChem ID: 5734
SMILES: C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
InchiKey: UBQNRHZMVUUOMG-UHFFFAOYSA-N
Therapeutic Category: Anticonvulsants, Antioxidants, Central Nervous System Agents, Protective Agents

Computed Drug Properties

Molecular Weight (dalton): 212.23
LogP: 0.6163
Ring Count: 2
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 86.19

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Phenytoin (57-41-0) Decreased Zonisamide Serum Level Antagonistic Uncertain The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Pain ADReCS
Abdominal Tenderness MetaADEDB
Abnormal Behaviour MetaADEDB
Abnormal Dreams ADReCS
Abnormal Eeg MetaADEDB
Abnormal Gait ADReCS
Abnormal Movements MetaADEDB
Abuse MetaADEDB
Accidental Injury ADReCS
Acetonaemia MetaADEDB
Acne ADReCS
Acute Psychosis PROTECT
Acute Sinusitis MetaADEDB
Adenitis MetaADEDB
Affect Lability PROTECT
Aggression PROTECT
Agitated MetaADEDB
Agitation ADReCS
Agranulocytoses MetaADEDB
Agranulocytosis PROTECT
Agraphia MetaADEDB
Alanine Aminotransferase Increased ADReCS
Albuminuria ADReCS
Alcohol Abuse MetaADEDB
Allergic Reaction ADReCS
Allergies MetaADEDB
Alopecia ADReCS
Altered State Of Consciousness ADReCS
Alveolitis Allergic PROTECT
Amblyopia ADReCS
Amenorrhoea ADReCS
Ammonia Increased MetaADEDB
Amnesia PROTECT
Anaemia ADReCS
Anaesthesia MetaADEDB
Anger PROTECT
Anhidrosis PROTECT
Ankle Fracture MetaADEDB
Anorexia ADReCS
Anti-Erythropoietin Antibody Positive MetaADEDB
Anticholinergic Syndrome MetaADEDB
Anticonvulsant Drug Level Increased MetaADEDB
Antidepressant Drug Level MetaADEDB
Antiphospholipid Syndrome MetaADEDB
Anxiety ADReCS
Apathy MetaADEDB
Aplasia Pure Red Cell MetaADEDB
Aplastic Anaemia PROTECT
Apnoea ADReCS
Apparent Death MetaADEDB
Application Site Erythema MetaADEDB
Application Site Rash MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arteriosclerosis MetaADEDB
Arthralgia ADReCS
Arthritis ADReCS
Arthropod Bite MetaADEDB
Aspartate Aminotransferase Increased ADReCS
Asthenia ADReCS
Ataxia ADReCS
Atrial Fibrillation ADReCS
Atrioventricular Block Complete MetaADEDB
Atrioventricular Block Second Degree MetaADEDB
Automatism MetaADEDB
Bacterial Pneumonia MetaADEDB
Binocular Eye Movement Disorder MetaADEDB
Bladder Pain ADReCS
Blindness Transient MetaADEDB
Blood Bicarbonate Decreased PROTECT
Blood Creatine Phosphokinase Increased PROTECT
Blood Creatinine Increased PROTECT
Blood Lactate Dehydrogenase Increased ADReCS
Blood Pressure Fluctuation MetaADEDB
Blood Thyroid Stimulating Hormone Increased MetaADEDB
Blood Urea Increased PROTECT
Blood Uric Acid MetaADEDB
Body Temperature Increased MetaADEDB
Bone Density Decreased MetaADEDB
Bone Marrow Failure MetaADEDB
Bradyarrhythmia MetaADEDB
Bradycardia ADReCS
Bradyphrenia PROTECT
Bradypnoea MetaADEDB
Breakthrough Bleeding MetaADEDB
Bruise MetaADEDB
Bruxism MetaADEDB
Burning Sensation MetaADEDB
C-Reactive Protein Increased MetaADEDB
Calculus Bladder ADReCS
Calculus Ureteric MetaADEDB
Calculus Urinary PROTECT
Cardiac Failure ADReCS
Cardiac Failure Acute MetaADEDB
Cardiac Fibrillation ADReCS
Cardiopulmonary Failure MetaADEDB
Cerebellar Atrophy MetaADEDB
Cerebellar Syndrome MetaADEDB
Cerebral Palsy MetaADEDB
Cerebral Vascular Disorder MetaADEDB
Cerebrovascular Accident ADReCS
Cerebrovascular Spasm MetaADEDB
Chest Pain ADReCS
Cholangitis ADReCS
Cholecystectomies MetaADEDB
Cholecystitis ADReCS
Cholecystitis Acute PROTECT
Cholelithiasis ADReCS
Chondrocalcinosis MetaADEDB
Chronic Fatigue Syndrome MetaADEDB
Circumoral Paresthesia ADReCS
Cns Depression Nos SIDER
Cognitive Disorder ADReCS
Cognitive Impairment ADReCS
Colitis ADReCS
Colitis Ischaemic MetaADEDB
Coma PROTECT
Complex Partial Seizures MetaADEDB
Compulsive Shopping MetaADEDB
Confabulation MetaADEDB
Confusional State ADReCS
Congenital Hiatus Hernia MetaADEDB
Conjunctivitis ADReCS
Constipation ADReCS
Convulsion ADReCS
Convulsions Grand Mal MetaADEDB
Coordination Abnormal ADReCS
Cough ADReCS
Cough Increased ADReCS
Coughing Blood MetaADEDB
Cramp Muscle SIDER
Cramps Of Lower Extremities SIDER
Deafness ADReCS
Decreased Appetite ADReCS
Dehydration ADReCS
Delusion MetaADEDB
Depressed Level Of Consciousness ADReCS
Depression ADReCS
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Dermatitis Medicamentosa MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Gastroparesis MetaADEDB
Diabetic Nephropathy MetaADEDB
Diabetic Neuropathy MetaADEDB
Diarrhoea ADReCS
Diplopia ADReCS
Discomfort ADReCS
Disease Of Liver MetaADEDB
Disturbance In Attention ADReCS
Disturbance In Sexual Arousal ADReCS
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drowsiness MetaADEDB
Drug Effect Decreased MetaADEDB
Drug Interaction MetaADEDB
Drug Reaction With Eosinophilia And Systemic Symptoms PROTECT
Drug Screen Positive MetaADEDB
Drug Tolerance MetaADEDB
Drug Toxicity MetaADEDB
Dry Mouth ADReCS
Dry Skin ADReCS
Duodenal Ulcer ADReCS
Duodenitis ADReCS
Dysarthria ADReCS
Dysgeusia ADReCS
Dyskinesia ADReCS
Dyspepsia ADReCS
Dysphagia ADReCS
Dyspnoea ADReCS
Dysthymic Disorder MetaADEDB
Dystonia ADReCS
Dysuria ADReCS
Early Morning Awakening MetaADEDB
Ecchymoses MetaADEDB
Ecchymosis ADReCS
Eczema ADReCS
Edentulous MetaADEDB
Electrocardiogram Pr Prolongation MetaADEDB
Electrocardiogram Qt Prolonged MetaADEDB
Embolism ADReCS
Embolus SIDER
Emesis MetaADEDB
Emphysema MetaADEDB
Emphysematous Bulla MetaADEDB
Encephalopathy ADReCS
Enuresis ADReCS
Eosinophil Count Increased MetaADEDB
Eosinophil Percentage Decreased MetaADEDB
Epilepsy MetaADEDB
Erectile Dysfunction ADReCS
Eruption MetaADEDB
Erythema Multiforme PROTECT
Erythromelalgia MetaADEDB
Euphoric Mood ADReCS
Excessive Salivation MetaADEDB
Excessive Thirst MetaADEDB
Excoriation MetaADEDB
Extrasystoles ADReCS
Extremity Pain MetaADEDB
Face Oedema ADReCS
Facial Palsy MetaADEDB
Facial Paralysis SIDER
Faecal Incontinence ADReCS
Fanconi Syndrome MetaADEDB
Fatigue ADReCS
Feeling Abnormal ADReCS
Flank Pain ADReCS
Flatulence ADReCS
Fluid Intake Reduced MetaADEDB
Foot Fracture MetaADEDB
Fungal Disease MetaADEDB
Gait Disturbance ADReCS
Gamma-Glutamyltransferase Increased MetaADEDB
Gastric Hyperplasia MetaADEDB
Gastritis ADReCS
Gastroduodenal Ulcer ADReCS
Gastroenteritis ADReCS
Gastrointestinal Pain ADReCS
Generalised Erythema MetaADEDB
Genital Erosion MetaADEDB
Gingival Bleeding ADReCS
Gingival Hyperplasia ADReCS
Gingivitis ADReCS
Glaucoma ADReCS
Glossitis ADReCS
Grand Mal Convulsion PROTECT
Granulocyte Count Decreased MetaADEDB
Gynaecomastia ADReCS
Haematemesis ADReCS
Haematuria ADReCS
Haemochromatosis MetaADEDB
Haemoglobin ADReCS
Haemoptysis ADReCS
Haemorrhage ADReCS
Haemorrhage Subcutaneous MetaADEDB
Haemorrhoids MetaADEDB
Hallucination PROTECT
Headache ADReCS
Heat Stroke PROTECT
Hemiplegia MetaADEDB
Hepatic Function Abnormal MetaADEDB
Hepatocellular Injury PROTECT
Hirsutism ADReCS
Homicidal Ideation MetaADEDB
Hospitalisation MetaADEDB
Hydrocephalus MetaADEDB
Hydronephrosis PROTECT
Hyperaesthesia ADReCS
Hyperhidrosis ADReCS
Hyperkinesia ADReCS
Hyperplasia ADReCS
Hyperreflexia ADReCS
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertonia ADReCS
Hyperventilation MetaADEDB
Hypoaesthesia MetaADEDB
Hypoglycaemia ADReCS
Hypokalaemia PROTECT
Hypokinesia ADReCS
Hypometabolism MetaADEDB
Hyponatraemia ADReCS
Hypotension ADReCS
Hypothyroid MetaADEDB
Hypotonia ADReCS
Hypovolaemia MetaADEDB
Ild MetaADEDB
Ill-Defined Disorder ADReCS
Immunodeficiency ADReCS
Impotence ADReCS
Incoherent MetaADEDB
Incontinence ADReCS
Incorrect Dose Administered MetaADEDB
Incorrect Route Of Drug Administration MetaADEDB
Increased Upper Airway Secretion MetaADEDB
Infection Urinary Tract MetaADEDB
Influenza ADReCS
Influenza Like Illness PROTECT
Insomnia ADReCS
Intestinal Ulcer MetaADEDB
Intracranial Tumour Haemorrhage MetaADEDB
Iritis ADReCS
Irritability ADReCS
Jaundice ADReCS
Jaundice Cholestatic ADReCS
Joint Sprain MetaADEDB
Lack Of Spontaneous Speech MetaADEDB
Lactic Dehydrogenase Activity Increased SIDER
Leg Cramps ADReCS
Leukoaraiosis MetaADEDB
Leukocytosis PROTECT
Leukoencephalopathy MetaADEDB
Leukopenia ADReCS
Libido Decreased ADReCS
Lip Erosion MetaADEDB
Liver Function Test Abnormal PROTECT
Lordosis MetaADEDB
Loss Of Consciousness ADReCS
Lung Edema MetaADEDB
Lupus Erythematosus SIDER
Lyell MetaADEDB
Lymphadenopathy ADReCS
Lymphocyte Morphology Abnormal MetaADEDB
Malaise ADReCS
Mania MetaADEDB
Masked Facies MetaADEDB
Mastitis ADReCS
Mean Cell Haemoglobin Increased MetaADEDB
Melaena ADReCS
Memory Impairment ADReCS
Menorrhagia ADReCS
Mental Disorder MetaADEDB
Mental Impairment ADReCS
Metabolic Acidosis PROTECT
Microcytic Anaemia ADReCS
Micturition Urgency ADReCS
Mood Altered MetaADEDB
Mood Swings PROTECT
Mouth Ulcer MetaADEDB
Mouth Ulceration ADReCS
Movement Disorder ADReCS
Mucosal Erosion MetaADEDB
Muscle Relaxant Therapy ADReCS
Muscle Rigidity ADReCS
Muscle Spasms ADReCS
Muscle Strain MetaADEDB
Muscle Twitching ADReCS
Muscular Weakness ADReCS
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Stiffness ADReCS
Myalgia ADReCS
Myasthenia SIDER
Myasthenic Syndrome PROTECT
Myoclonus ADReCS
Nausea ADReCS
Near Syncope MetaADEDB
Neck Stiffness ADReCS
Nephrolithiasis PROTECT
Nervous Tension MetaADEDB
Nervousness ADReCS
Neumonia MetaADEDB
Neuritis ADReCS
Neurogenic Bladder MetaADEDB
Neuroleptic Malignant Syndrome PROTECT
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Neutralising Antibodies MetaADEDB
Neutrophil Count Decreased MetaADEDB
Nocturia ADReCS
Nuchal Rigidity ADReCS
Nuclear Magnetic Resonance Imaging Abnormal MetaADEDB
Nuclear Magnetic Resonance Imaging Brain Abnormal MetaADEDB
Nystagmus ADReCS
Oculogyric Crisis ADReCS
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophagitis ADReCS
Oral Intake Reduced MetaADEDB
Osteoarthritis ADReCS
Pacemaker Generated Rhythm MetaADEDB
Pain ADReCS
Pain Pelvic MetaADEDB
Palpitation MetaADEDB
Palpitations ADReCS
Pancreatitis PROTECT
Pancytopenia PROTECT
Paraesthesia ADReCS
Paraesthesia Oral ADReCS
Paralysis ADReCS
Parkinson MetaADEDB
Parosmia ADReCS
Pathogen Resistance MetaADEDB
Penile Pain MetaADEDB
Peripheral Neuritis ADReCS
Perivascular Dermatitis MetaADEDB
Personality Change MetaADEDB
Petechiae ADReCS
Pharyngitis ADReCS
Photophobia ADReCS
Pigmentation Disorder MetaADEDB
Pleurisy MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia PROTECT
Pneumonia Aspiration PROTECT
Pollakiuria ADReCS
Polyuria ADReCS
Positron Emission Tomogram Abnormal MetaADEDB
Post Laminectomy Syndrome MetaADEDB
Post Procedural Infection MetaADEDB
Posture Abnormal MetaADEDB
Pre-Existing Condition Improved MetaADEDB
Prostate Cancer Recurrent MetaADEDB
Prostatic Abscess MetaADEDB
Pruritus ADReCS
Psychiatric Symptom MetaADEDB
Psychotic Disorder ADReCS
Pulmonary Embolism ADReCS
Pulmonary Mass MetaADEDB
Pyelonephritis MetaADEDB
Pyothorax MetaADEDB
Pyrexia PROTECT
Rash ADReCS
Rash Generalised MetaADEDB
Rash Maculo-Papular ADReCS
Rash Pustular ADReCS
Rectal Haemorrhage ADReCS
Renal Failure PROTECT
Renal Impairment MetaADEDB
Renal Tubular Acidosis PROTECT
Renal Tubular Disorder MetaADEDB
Respiratory Disorder PROTECT
Retrocollis MetaADEDB
Reversible Posterior Leukoencephalopathy Syndrome MetaADEDB
Rhabdomyolysis PROTECT
Rhinitis ADReCS
Schizophreniform Disorder ADReCS
Scleroderma MetaADEDB
Scotoma ADReCS
Sensation Of Heaviness MetaADEDB
Shock ADReCS
Skin Desquamation MetaADEDB
Skin Hypertrophy MetaADEDB
Somnolence ADReCS
Speech Disorder ADReCS
Speech Impairment Nos SIDER
Status Epilepticus PROTECT
Stevens-Johnson Syndrome PROTECT
Stomatitis ADReCS
Stress MetaADEDB
Sudden Unexplained Death In Epilepsy PROTECT
Suicidal Ideation PROTECT
Suicide Attempt PROTECT
Sweating SIDER
Syncope ADReCS
Systemic Lupus Erythematosus ADReCS
Tachycardia ADReCS
Tachycardia Ventricular MetaADEDB
Tension ADReCS
Thirst ADReCS
Thrombocytopenia ADReCS
Thrombophlebitis ADReCS
Tinnitus ADReCS
Tooth Loss MetaADEDB
Toxic Epidermal Necrolysis PROTECT
Toxic Skin Eruption MetaADEDB
Transmission Of An Infectious Agent Via A Medicinal Product MetaADEDB
Tremor ADReCS
Tubulointerstitial Nephritis MetaADEDB
Ulcer ADReCS
Ulcerative Stomatitis SIDER
Unresponsive To Stimuli MetaADEDB
Urinary Incontinence ADReCS
Urinary Retention ADReCS
Urinary Tract Infection PROTECT
Urine Abnormality PROTECT
Urine Analysis Abnormal PROTECT
Urine Output Increased ADReCS
Urine Phosphate Increased MetaADEDB
Urine Potassium Increased MetaADEDB
Urticaria ADReCS
Vascular Insufficiency ADReCS
Ventricular Extrasystoles ADReCS
Ventriculo-Peritoneal Shunt MetaADEDB
Vertigo ADReCS
Vesiculobullous Rash SIDER
Viith Nerve Paralysis ADReCS
Viraemia MetaADEDB
Visual Field Defect ADReCS
Vomiting ADReCS
Walking Aid User MetaADEDB
Weight Decreased ADReCS
Weight Increased ADReCS
Wound Secretion MetaADEDB
Zinc Sulphate Turbidity Decreased MetaADEDB

InAADR: Drug-Protein-ADRs database