| Drug Name: | Vincristine (57-22-7) |
|---|---|
| PubChem ID: | 45358158 |
| SMILES: | CC[C@@]1(C[C@@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7[C@@](C=CC9)([C@H]([C@@](C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O |
| InchiKey: | OGWKCGZFUXNPDA-DLBZMDDPSA-N |
| Therapeutic Category: | Antimitotic Agents, Antineoplastic Agents, Mitosis Modulators, Tubulin Modulators |
| Molecular Weight (dalton) | : | 824.972 |
| LogP | : | 3.5175 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 12 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 171.17 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Itraconazole (84625-61-6) | Neurotoxicity | Synergistic | Not understood | Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL |
| Itraconazole (84625-61-6) | Paraesthesia | Synergistic | Not understood | Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category