| Drug Name: | Tretinoin (302-79-4) |
|---|---|
| PubChem ID: | 444795 |
| SMILES: | CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C |
| InchiKey: | SHGAZHPCJJPHSC-YCNIQYBTSA-N |
| Therapeutic Category: | Antineoplastic Agents, Dermatologic Agents, Keratolytic Agents |
| Molecular Weight (dalton) | : | 300.442 |
| LogP | : | 5.6026 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 1 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 37.3 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Fluconazole (86386-73-4) | Headache | Synergistic | Fluconazole inhibits the cytochrome P450 isoenzymes CYP3A4 and CYP2C9, which are amongst those involved in the oxidative metabolism of tretinoin | Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia |
| Fluconazole (86386-73-4) | Papilloedema | Synergistic | Fluconazole inhibits the cytochrome P450 isoenzymes CYP3A4 and CYP2C9, which are amongst those involved in the oxidative metabolism of tretinoin | Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia |
| Fluconazole (86386-73-4) | Vomiting | Synergistic | Fluconazole inhibits the cytochrome P450 isoenzymes CYP3A4 and CYP2C9, which are amongst those involved in the oxidative metabolism of tretinoin | Interaction of all-trans-retinoic acid with fluconazole in acute promyelocytic leukemia |
| Tranexamic Acid (1197-18-8) | Kidney Cortex Necrosis | Additive | Tretinoin alone causes a procoagulant tendency in acute promyelocytic leukaemia (APL) and this may be exacerbated by use of antifibrinolytics. | All-Trans Retinoic Acid (Atra) and Tranexamic Acid: A Potentially Fatal Combination In Acute Promyelocytic Leukaemia |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category