This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Mood-Stabilizing Effects | corticotropin-releasing hormone (CRH) (P34998) | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line #depressed# rats and upregulates NPY@ galanin@ and CRH-LI in the hypothalamus@which plays a role for mood-stabilizing and weight loss-inducing effects. [ ADR Type 2 3 ] | A Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-induce
|
| Mood-Stabilizing Effects | Galanin (P22466) | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line #depressed# rats and upregulates NPY@ galanin@ and CRH-LI in the hypothalamus@which plays a role for mood-stabilizing and weight loss-inducing effects [ ADR Type 2 3 ] | A Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-induce
|
| Mood-Stabilizing Effects | Neuropeptide Y (P01303) | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line #depressed# rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus,which plays a role for mood-stabilizing and weight loss-inducing effects. [ ADR Type 2 3 ] | A Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-induce
|
| Weight Loss-Inducing Effects | corticotropin-releasing hormone (CRH) (P34998) | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line #depressed# rats and upregulates NPY@ galanin@ and CRH-LI in the hypothalamus@which plays a role for mood-stabilizing and weight loss-inducing effects. [ ADR Type 2 3 ] | A Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-induce
|
| Weight Loss-Inducing Effects | Galanin (P22466) | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line #depressed# rats and upregulates NPY@ galanin@ and CRH-LI in the hypothalamus@which plays a role for mood-stabilizing and weight loss-inducing effects [ ADR Type 2 3 ] | A Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-induce
|
| Weight Loss-Inducing Effects | Neuropeptide Y (P01303) | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line #depressed# rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus,which plays a role for mood-stabilizing and weight loss-inducing effects. [ ADR Type 2 3 ] | A Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-induce
|