InAADR

Drug Information

Drug Name: Tolcapone (134308-13-7)
PubChem ID: 4659569
SMILES: CC1=CC=C(C=C1)C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-]
InchiKey: MIQPIUSUKVNLNT-UHFFFAOYSA-N
Therapeutic Category: Anti-Dyskinesia Agents, Antiparkinson Agents, Catechol O-Methyltransferase Inhibitors, Central Nervous System Agents, Enzyme Inhibitors

Computed Drug Properties

Molecular Weight (dalton): 273.244
LogP: 2.54542
Ring Count: 2
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 100.67

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Compartment Syndrome MetaADEDB
Abdominal Pain ADReCS
Abnormal Behaviour MetaADEDB
Abnormal Dreams ADReCS
Abnormal Eeg MetaADEDB
Abnormal Faeces ADReCS
Abnormal Gait MetaADEDB
Abnormal Lfts MetaADEDB
Abnormal Movements MetaADEDB
Abscess ADReCS
Accidental Injury ADReCS
Acetonaemia MetaADEDB
Aching Muscles MetaADEDB
Acute Coronary Syndrome ADReCS
Acute Hepatic Failure ADReCS
Acute Myocardial Infarction MetaADEDB
Adenocarcinoma MetaADEDB
Adenopathy MetaADEDB
Affect Lability ADReCS
Affective Disorder MetaADEDB
Agitation ADReCS
Agraphia MetaADEDB
Akinesia MetaADEDB
Alanine Aminotransferase Increased PROTECT
Allergic Reaction ADReCS
Alopecia ADReCS
Amnesia ADReCS
Anaemia ADReCS
Angina Pectoris ADReCS
Anorectal Disorder ADReCS
Anorexia ADReCS
Anosmia MetaADEDB
Antinuclear Antibody MetaADEDB
Antisocial Behaviour ADReCS
Antisocial Personality Disorder ADReCS
Anxiety ADReCS
Aortic Stenosis ADReCS
Aortic Valve Sclerosis MetaADEDB
Aortic Valve Stenosis ADReCS
Apathy ADReCS
Apnoea ADReCS
Application Site Scar MetaADEDB
Arrhythmia ADReCS
Arterial Disorder ADReCS
Arterial Pressure Nos Decreased MetaADEDB
Arterial Spasm ADReCS
Arteriosclerosis ADReCS
Arthralgia ADReCS
Arthritis ADReCS
Arthropathy ADReCS
Asocial Behaviour ADReCS
Aspartate Aminotransferase Increase MetaADEDB
Asthenia ADReCS
Asthma ADReCS
Atrial Fibrillation ADReCS
Automatism MetaADEDB
Bacterial Infection ADReCS
Balance Disorder ADReCS
Basal Ganglion Degeneration MetaADEDB
Biliary Cirrhosis MetaADEDB
Blepharospasm MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Fibrinogen MetaADEDB
Blood Iron Increased MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Body Temperature Increased ADReCS
Bradycardia ADReCS
Bradypnoea MetaADEDB
Breast Neoplasm ADReCS
Bronchitis ADReCS
Burning Sensation ADReCS
Calculus Bladder ADReCS
Calculus Of Kidney SIDER
Carcinoma SIDER
Cardiac Arrest ADReCS
Cardiac Failure ADReCS
Cardiac Fibrillation ADReCS
Cardiovascular Disorder ADReCS
Cartilage Development Disorder MetaADEDB
Cataract ADReCS
Cellulitis ADReCS
Cerebellar Syndrome MetaADEDB
Cerebral Haemorrhage ADReCS
Cerebral Ischaemia ADReCS
Cerebrovascular Accident ADReCS
Chest Discomfort ADReCS
Chest Pain ADReCS
Chill MetaADEDB
Chills ADReCS
Cholecystitis ADReCS
Cholelithiasis ADReCS
Choreoathetosis ADReCS
Chromaturia ADReCS
Cogwheel Rigidity MetaADEDB
Colitis ADReCS
Colitis Ischaemic MetaADEDB
Condition Aggravated MetaADEDB
Confusional State ADReCS
Constipation ADReCS
Convulsions Grand Mal MetaADEDB
Coronary Artery Disease ADReCS
Cough ADReCS
Cough Increased ADReCS
Cramp MetaADEDB
Cramp Muscle SIDER
Cytolytic Hepatitis ADReCS
Death ADReCS
Decreased Appetite ADReCS
Decubitus Ulcer MetaADEDB
Deep Vein Thromboses MetaADEDB
Dehydration ADReCS
Delirium ADReCS
Delusion ADReCS
Depression ADReCS
Dermatitis ADReCS
Diabetes Mellitus ADReCS
Diarrhoea ADReCS
Difficulty In Walking MetaADEDB
Diplopia ADReCS
Discomfort ADReCS
Disturbance In Attention MetaADEDB
Disturbance In Sexual Arousal ADReCS
Dizziness ADReCS
Drug Chemical Incompatibility MetaADEDB
Drug Ineffective MetaADEDB
Dry Mouth ADReCS
Duodenal Ulcer ADReCS
Dysgeusia ADReCS
Dyskinesia ADReCS
Dyspepsia ADReCS
Dysphagia ADReCS
Dyspnoea ADReCS
Dysthymic Disorder MetaADEDB
Dystonia ADReCS
Dysuria ADReCS
Ear Infection ADReCS
Ear Pain ADReCS
Eczema ADReCS
Effusion ADReCS
Embolism ADReCS
Embolus SIDER
Encephalopathy ADReCS
Epistaxis ADReCS
Erectile Dysfunction ADReCS
Erythema ADReCS
Erythema Multiforme ADReCS
Euphoric Mood ADReCS
Excessive Salivation MetaADEDB
Extrapyramidal Disorder ADReCS
Eye Haemorrhage ADReCS
Eye Inflammation ADReCS
Eye Pain ADReCS
Eye Rolling MetaADEDB
Face Oedema ADReCS
Facial Neuralgia MetaADEDB
Fall ADReCS
Fatigue ADReCS
Feeling Abnormal ADReCS
Feeling Guilty MetaADEDB
Femoral Hernia MetaADEDB
Fib MetaADEDB
Flank Pain ADReCS
Flat Affect ADReCS
Flatulence ADReCS
Flight Of Ideas MetaADEDB
Flu MetaADEDB
Formication MetaADEDB
Fracture ADReCS
Fungal Infection ADReCS
Furuncle ADReCS
Furunculosis SIDER
Gait Disturbance ADReCS
Gall Bladder MetaADEDB
Gambling MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gastric Atony ADReCS
Gastric Disorder ADReCS
Gastroenteritis ADReCS
Gastrointestinal Carcinoma ADReCS
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Pain ADReCS
General Physical Health Deterioration MetaADEDB
Glaucoma ADReCS
Glucose Urine MetaADEDB
Haematuria ADReCS
Haemoglobin ADReCS
Haemorrhage ADReCS
Haemorrhage Subepidermal ADReCS
Hallucination ADReCS
Hallucinations Mixed MetaADEDB
Headache ADReCS
Heart Attack MetaADEDB
Hemiplegia ADReCS
Hepatic Enzyme MetaADEDB
Hepatic Failure MetaADEDB
Hepatic Necrosis MetaADEDB
Hepatitis ADReCS
Hepatitis Fulminant MetaADEDB
Hepatitis Viral ADReCS
Hepatocellular Injury ADReCS
Hepatotoxicity MetaADEDB
Hernia ADReCS
Herpes Nos SIDER
Herpes Simplex ADReCS
Herpes Virus Infection ADReCS
Herpes Zoster ADReCS
Hiccups ADReCS
Homicidal Ideation MetaADEDB
Hostility ADReCS
Hyperalimentation MetaADEDB
Hypercholesterolaemia ADReCS
Hyperhidrosis ADReCS
Hyperkinesia ADReCS
Hypersensitivity ADReCS
Hypersexuality ADReCS
Hypertension ADReCS
Hypertonia ADReCS
Hyperventilation ADReCS
Hypoaesthesia ADReCS
Hypokinesia ADReCS
Hypophagia MetaADEDB
Hypotension ADReCS
Hypoxia ADReCS
Ill-Defined Disorder ADReCS
Impaired Gastric Emptying ADReCS
Impotence ADReCS
Incontinence ADReCS
Increased Appetite MetaADEDB
Infantile Spasms MetaADEDB
Infarction ADReCS
Infection ADReCS
Influenza ADReCS
Infusion Site Mobility Decreased MetaADEDB
Intention Tremor MetaADEDB
Intervertebral Disc Herniation MetaADEDB
Intra-abdominal haematoma MetaADEDB
Irritability ADReCS
Ischaemia ADReCS
Ischaemic Stroke MetaADEDB
Lacrimal Disorder ADReCS
Lacrimation SIDER
Lacrimation Increased ADReCS
Laryngitis ADReCS
Lethargy ADReCS
Leukaemia ADReCS
Libido Decreased ADReCS
Libido Increased ADReCS
Liver Injury ADReCS
Loss Of Consciousness ADReCS
Loss Of Weight MetaADEDB
Lung Fibrosis MetaADEDB
Lymphocytes Decreased MetaADEDB
Malaise ADReCS
Mania ADReCS
Manic Psychosis SIDER
Masked Facies MetaADEDB
Meningitis ADReCS
Mental Deficiency SIDER
Mental Disability ADReCS
Mental Disorder SIDER
Mental Impairment MetaADEDB
Mental Retardation ADReCS
Metastases To Liver MetaADEDB
Micturition Disorder ADReCS
Migraine ADReCS
Mood Swings ADReCS
Motor Dysfunction MetaADEDB
Mouth Ulceration ADReCS
Movement Disorder MetaADEDB
Multi-Organ Failure MetaADEDB
Muscle Spasms ADReCS
Muscle Twitching ADReCS
Musculoskeletal Discomfort ADReCS
Musculoskeletal Stiffness ADReCS
Myalgia ADReCS
Myocardial Infarction ADReCS
Myocardial Ischaemia ADReCS
Myoclonus ADReCS
Nausea ADReCS
Neck Pain ADReCS
Neoplasm ADReCS
Neoplasm Malignant ADReCS
Neoplasm Skin ADReCS
Nephrolithiasis ADReCS
Nerve Conduction Studies Abnormal MetaADEDB
Nervousness ADReCS
Neuralgia ADReCS
Neuroleptic Malignant Syndrome PROTECT
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Neutrophilia MetaADEDB
Nocturia ADReCS
Nuclear Magnetic Resonance Imaging Brain Abnormal MetaADEDB
Ocular Hyperaemia ADReCS
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophagitis ADReCS
Oliguria ADReCS
Orthostatic Intolerance ADReCS
Osteoarthritis ADReCS
Otitis SIDER
Otitis Media ADReCS
Ovarian Cancer ADReCS
Ovarian Carcinoma SIDER
Pain ADReCS
Pain In Extremity ADReCS
Palpitations ADReCS
Palsies MetaADEDB
Panic Reaction ADReCS
Paraesthesia ADReCS
Paranoia ADReCS
Paranoid Reaction SIDER
Paresis ADReCS
Parosmia ADReCS
Pathological Gambling ADReCS
Performance Status Decreased MetaADEDB
Pericardial Effusion ADReCS
Periorbital Oedema ADReCS
Pharyngitis ADReCS
Pleural Fibrosis MetaADEDB
Pneumonia ADReCS
Pollakiuria ADReCS
Polyuria ADReCS
Portal Hypertension MetaADEDB
Posture Abnormal MetaADEDB
Prostate Cancer ADReCS
Prostate Carcinoma SIDER
Prostatic Disorder ADReCS
Pruritus ADReCS
Psychomotor Hyperactivity ADReCS
Psychotic Disorder ADReCS
Pulmonary Arrest MetaADEDB
Pulmonary Embolism ADReCS
Pulmonary Oedema ADReCS
Pyrexia ADReCS
Rash ADReCS
Rectal Disorder SIDER
Regressive Behaviour MetaADEDB
Respiratory Tract Infection ADReCS
Rhabdomyolysis PROTECT
Rhinitis ADReCS
Salivary Hypersecretion ADReCS
Salivation SIDER
Seborrhoea ADReCS
Seborrhoeic Dermatitis ADReCS
Shock ADReCS
Sinus Congestion ADReCS
Sinusitis ADReCS
Skin Discolouration ADReCS
Skin Disorder ADReCS
Sleep Disorder ADReCS
Sleep Walking MetaADEDB
Somnolence ADReCS
Speech Disorder ADReCS
Spinal Column Stenosis MetaADEDB
Stiffness SIDER
Stomatitis ADReCS
Stress MetaADEDB
Surgery ADReCS
Sweating SIDER
Sweating Increased SIDER
Syncope ADReCS
Tachycardia ADReCS
Taste Alteration ADReCS
Tenosynovitis ADReCS
Tension ADReCS
Therapy Non-Responder MetaADEDB
Therapy Regimen Changed MetaADEDB
Thinking Abnormal ADReCS
Thirst ADReCS
Thrombocytopenia ADReCS
Thrombosis ADReCS
Tinnitus ADReCS
Tongue Disorder ADReCS
Tongue Paralysis MetaADEDB
Tooth Disorder ADReCS
Tremor ADReCS
Ulcer ADReCS
Upper Respiratory Tract Infection ADReCS
Urethral Disorder SIDER
Urinary Incontinence ADReCS
Urinary Retention ADReCS
Urinary Tract Disorder ADReCS
Urinary Tract Infection ADReCS
Urine Colour Abnormal ADReCS
Urine Output Increased ADReCS
Urticaria ADReCS
Uterine Atony ADReCS
Uterine Disorder ADReCS
Uterine Haemorrhage ADReCS
Uterine Hypotonus ADReCS
Uterine Neoplasm ADReCS
Vaginal Infection ADReCS
Vaginal Inflammation ADReCS
Vasodilation SIDER
Vasodilation Procedure ADReCS
Vertigo ADReCS
Viral Infection ADReCS
Vision Blurred ADReCS
Vomiting ADReCS
Weight Decreased ADReCS
Withdrawal Syndrome PROTECT

InAADR: Drug-Protein-ADRs database