| Drug Name: | Simvastatin (79902-63-9) |
|---|---|
| PubChem ID: | 54454 |
| SMILES: | CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C |
| InchiKey: | RYMZZMVNJRMUDD-HGQWONQESA-N |
| Therapeutic Category: | Anticholesteremic Agents, Antimetabolites, Enzyme Inhibitors, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypolipidemic Agents, Lipid Regulating Agents |
| Molecular Weight (dalton) | : | 418.574 |
| LogP | : | 4.5856 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 72.83 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Daptomycin (103060-53-3) | Increased Risk Of Muscle Toxicity | Additive | Not understood | Severe myopathy and possible hepatotoxicity related to daptomycin |
| Clopidogrel (113665-84-2) | Reduce The Antiplatelet Effect Of Clopidogrel | Antagonistic | Simvastatins metabolised by CYP3A4 can cause a reduction in the antiplatelet activity of clopidogrel | Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function — a flow cytometry study |
This panel provides drug-protein interaction and their ADRs along with references
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|---|---|
| Grapefruit Juice | Acute Renal Failure | Food–drug interaction: grapefruit juice augments drug bioavailabilityFmechanism, extent and relevance |
| Grapefruit Juice | Rhabdomyolysis | Food–drug interaction: grapefruit juice augments drug bioavailabilityFmechanism, extent and relevance |
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category