| Drug Name: | Quinapril (85441-61-8) |
|---|---|
| PubChem ID: | 54892 |
| SMILES: | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3=CC=CC=C3C[C@H]2C(=O)O |
| InchiKey: | JSDRRTOADPPCHY-HSQYWUDLSA-N |
| Therapeutic Category: | Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cardiovascular Agents, Enzyme Inhibitors, Protease Inhibitors |
| Molecular Weight (dalton) | : | 438.524 |
| LogP | : | 2.5671 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 95.94 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Trimethoprim (738-70-5) | Hyperkalaemia | Antagonistic | Trimethoprim have a potassium-sparing effect on the distal part of the kidney tubules and ACE inhibitors reduce aldosterone synthesis, which results in reduced renal loss of potassium | Severe hyperkalemia with trimethoprim-quinapril |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Bradycardia | Angiotensin-converting enzyme precursor (P12821) | Renoprotective effects@ blood-pressure reduction@ reduction in left ventricular mass@ endothelial function [ ADR Type 1 ] | Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients-- interaction with ACE insertion/deletion polymorphism Kidney |
| Cough | B2 bradykinin receptor (P30411) | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. [ ADR Type 2 ] | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category