| Drug Name: | Prednisolone (50-24-8) |
|---|---|
| PubChem ID: | 5755 |
| SMILES: | C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O |
| InchiKey: | OIGNJSKKLXVSLS-VWUMJDOOSA-N |
| Therapeutic Category: | Adrenal Cortex Hormones, Anti-Inflammatory Agents, Antineoplastic Agents, Glucocorticoids, Hormones |
| Molecular Weight (dalton) | : | 360.45 |
| LogP | : | 1.5576 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 94.83 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Apoptosis | DNA topoisomerase 1 (P11387) | Rat thymocytes were treated in culture with prednisolone or the DNA topoisomerase I or II inhibitors@The appearance of apoptotic cells in cultures treated with pharmacological concentrations of these drugs@ observed as early as 3-6 hr after treatment@ coincided with the selective loss of G0 cells in these cultures [ ADR Type 1 ] | Apoptosis of rat thymocytes triggered by prednisolone, camptothecin, or teniposide is selective to G0 cells and is prevented by inhibitors of proteases |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category