| Drug Name: | Practolol (6673-35-4) |
|---|---|
| PubChem ID: | 4883 |
| SMILES: | CC(C)NCC(COC1=CC=C(C=C1)NC(=O)C)O |
| InchiKey: | DURULFYMVIFBIR-UHFFFAOYSA-N |
| Therapeutic Category: | Adrenergic Agents, Adrenergic Antagonists, Adrenergic beta-1 Receptor Antagonists, Adrenergic beta-Antagonists, Anti-Arrhythmia Agents, Cardiovascular Agents, Neurotransmitter Agents |
| Molecular Weight (dalton) | : | 266.341 |
| LogP | : | 1.3827 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 70.59 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Disopyramide ((3737-09-5)) | Bradycardia | Additive | Not understood. Both disopyramide and the beta blockers can depress the contractility and conductivity of the heart muscle | Cardiovascular safety of sublingual apomorphine in patients on stable doses of oral antihypertensive agents and nitrates |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Increased Beta-Blockade | CYP2D6 (P10635) | Increased beta-blockade [ ADR Type 1 ] | Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category