InAADR

Drug Information

Drug Name: Pioglitazone (111025-46-8)
PubChem ID: 4829
SMILES: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
InchiKey: HYAFETHFCAUJAY-UHFFFAOYSA-N
Therapeutic Category: Hypoglycemic Agents

Computed Drug Properties

Molecular Weight (dalton): 356.447
LogP: 3.1596
Ring Count: 2
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 68.29

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Mass MetaADEDB
Abnormal Dreams MetaADEDB
Abnormal Ecg MetaADEDB
Abnormal Loss Of Weight MetaADEDB
Abuse MetaADEDB
Acetonaemia MetaADEDB
Aching Joints MetaADEDB
Acquired Diaphragmatic Eventration MetaADEDB
Acromegaly MetaADEDB
Acute Coronary Syndrome ADReCS
Acute Generalised Exanthematous Pustulosis MetaADEDB
Acute Pancreatitis MetaADEDB
Acute Respiratory Distress Syndrome MetaADEDB
Acute Sinusitis MetaADEDB
Adh Inappropriate MetaADEDB
Afib MetaADEDB
Alanine Aminotransferase Decreased ADReCS
Alanine Aminotransferase Increased ADReCS
Allergic Rhinitis MetaADEDB
Allergies MetaADEDB
Altered State Of Consciousness MetaADEDB
Alveoloplasty MetaADEDB
Amentia MetaADEDB
Amnestic Disorder MetaADEDB
Amyotrophy MetaADEDB
Anaemia ADReCS
Anaesthesia MetaADEDB
Anal Fistula MetaADEDB
Anaphylactic Reaction PROTECT
Angioedema PROTECT
Anhedonia MetaADEDB
Anti-Insulin Antibody Positive MetaADEDB
Antinuclear Antibody MetaADEDB
Aortic Arteriosclerosis MetaADEDB
Aortic Disorder MetaADEDB
Aortic Valve Sclerosis MetaADEDB
Apoplexy MetaADEDB
Application Site Dermatitis MetaADEDB
Application Site Erythema MetaADEDB
Application Site Pruritus MetaADEDB
Application Site Reaction MetaADEDB
Aptyalism MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arterial Stenosis MetaADEDB
Arterial Stent Insertion MetaADEDB
Arteriosclerosis MetaADEDB
Arteriosclerosis Coronary Artery MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arteriovenous Malformation MetaADEDB
Arthralgia PROTECT
Arthritis Rheumatoid MetaADEDB
Arthropod Bite MetaADEDB
Artificial Crown Procedure MetaADEDB
Ascites MetaADEDB
Aspartate Aminotransferase Decreased ADReCS
Aspiration Joint MetaADEDB
Asthenia MetaADEDB
Asthma MetaADEDB
Atelectasis MetaADEDB
Atrial Flutter MetaADEDB
Atrial Septal Defect MetaADEDB
Atrial Tachycardia MetaADEDB
Av Dissociation MetaADEDB
Azotaemia MetaADEDB
Back Ache MetaADEDB
Back Pain ADReCS
Bacteraemia MetaADEDB
Bacterial Pneumonia MetaADEDB
Bad Breath MetaADEDB
Basal Cell Carcinoma MetaADEDB
Beta Haemolytic Streptococcal Infection MetaADEDB
Birth Defect MetaADEDB
Bladder Cancer ADReCS
Bladder Neoplasm ADReCS
Blood Alkaline Phosphatase Decreased ADReCS
Blood Bilirubin Decreased ADReCS
Blood Calcium Increased MetaADEDB
Blood Cholesterol MetaADEDB
Blood Creatine Phosphokinase Increased ADReCS
Blood Creatinine Increased MetaADEDB
Blood Electrolytes Decreased MetaADEDB
Blood Glucose Abnormal MetaADEDB
Blood Glucose Decreased MetaADEDB
Blood Glucose Fluctuation MetaADEDB
Blood Lactate Dehydrogenase Increased PROTECT
Blood Magnesium Decreased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Pressure Inadequately Controlled MetaADEDB
Blood Testosterone Decreased MetaADEDB
Blood Urea Increased MetaADEDB
Bone Cancer Metastatic MetaADEDB
Bone Erosion MetaADEDB
Bone Marrow Failure MetaADEDB
Brain Herniation MetaADEDB
Brain Mass MetaADEDB
Breast Cancer Metastatic MetaADEDB
Breast Lump MetaADEDB
Breast Oedema MetaADEDB
Breast Pain MetaADEDB
Breast Swelling MetaADEDB
Bronchitis PROTECT
Bruise MetaADEDB
Bruxism MetaADEDB
Bulging MetaADEDB
Bundle Branch Block Left MetaADEDB
C-Reactive Protein Increased MetaADEDB
Cancer Pain MetaADEDB
Carbuncle MetaADEDB
Carcinogenicity SIDER
Cardiac Decompensation MetaADEDB
Cardiac Discomfort ADReCS
Cardiac Failure ADReCS
Cardiac Failure Acute MetaADEDB
Cardiac Failure Congestive ADReCS
Cardiac Pacemaker Insertion MetaADEDB
Cardiac Ventricular Disorder MetaADEDB
Carotid Artery Disease MetaADEDB
Cartilage Injury MetaADEDB
Cataract Nuclear MetaADEDB
Cataract Operation MetaADEDB
Cellulitis MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerebral Cyst MetaADEDB
Cervical Discharge MetaADEDB
Chest Pain ADReCS
Chill MetaADEDB
Cholecystitis Chronic MetaADEDB
Chronic Kidney Disease MetaADEDB
Clotting MetaADEDB
Clubbing MetaADEDB
Clumsiness MetaADEDB
Colon Spastic MetaADEDB
Color Blindness MetaADEDB
Colpitis MetaADEDB
Compulsive Shopping MetaADEDB
Congenital Cystic Kidney Disease MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Creatine Phosphokinase Increased SIDER
Deglutition Disorder MetaADEDB
Dehydration MetaADEDB
Dental Abscess MetaADEDB
Dental Care MetaADEDB
Dental Operation MetaADEDB
Dental Pain MetaADEDB
Dental Prosthesis Placement MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Dermatomyositis MetaADEDB
Device Related Infection MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus SIDER
Diabetes Mellitus Aggravated ADReCS
Diabetes Mellitus Exacerbated SIDER
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Insulin-Dependent MetaADEDB
Diabetes Mellitus Malnutrition-Related MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Acidosis MetaADEDB
Diabetic Complication MetaADEDB
Diabetic Foot MetaADEDB
Diabetic Hyperosmolar Coma MetaADEDB
Diabetic Macular Edema SIDER
Diabetic Nephropathy MetaADEDB
Diabetic Neuropathy MetaADEDB
Diabetic Retinal Oedema ADReCS
Diabetic Retinopathy MetaADEDB
Diabetic Vascular Disorder MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Disease Progression ADReCS
Disorder Lung MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Diverticular Perforation MetaADEDB
Diverticulitis MetaADEDB
Dizziness ADReCS
Dry Throat MetaADEDB
Dysgeusia MetaADEDB
Dyslipidaemia MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea PROTECT
Dysstasia MetaADEDB
Ebv Infection MetaADEDB
Ecg Signs Of Ventricular Hypertrophy MetaADEDB
Eczema MetaADEDB
Edema Extremities MetaADEDB
Electrocardiogram Abnormal SIDER
Electrocardiogram Change MetaADEDB
Electrolyte Disorder MetaADEDB
Emesis MetaADEDB
Emotional Distress MetaADEDB
Endodontic Procedure MetaADEDB
Enterovesical Fistula MetaADEDB
Erectile Dysfunction PROTECT
Erythema Migrans MetaADEDB
Erythremia MetaADEDB
Eustachian Tube Disorder MetaADEDB
Excess Potassium MetaADEDB
Excoriation MetaADEDB
Expired Drug Administered MetaADEDB
Face Pain MetaADEDB
Facial Neuralgia MetaADEDB
Factor V Leiden Mutation MetaADEDB
Faecaloma MetaADEDB
Fat Necrosis MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue PROTECT
Fistula MetaADEDB
Flatulence ADReCS
Fluid Intake Reduced MetaADEDB
Fluid Retention ADReCS
Fracture ADReCS
Fungal Disease MetaADEDB
Fusobacterium Infection MetaADEDB
Gallbladder Perforation MetaADEDB
Gamma-Glutamyltransferase Decreased ADReCS
Gangrene MetaADEDB
Gastric Bypass MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Disorder MetaADEDB
Gastrointestinal Ulcer MetaADEDB
Generalised Oedema ADReCS
Gestational Diabetes MetaADEDB
Gingival Disorder MetaADEDB
Gingival Pain MetaADEDB
Glycosuria PROTECT
Glycosylated Haemoglobin Increased MetaADEDB
Goiter MetaADEDB
Gout MetaADEDB
Growth Hormone Deficiency MetaADEDB
Haematocrit Decreased ADReCS
Haematocrit Increased MetaADEDB
Haematuria PROTECT
Haemoglobin Decreased ADReCS
Haemorrhage Rectum MetaADEDB
Haemorrhoids MetaADEDB
Headache ADReCS
Heart Attack MetaADEDB
Hepatic Enzyme Increased PROTECT
Hepatic Failure ADReCS
Hepatocellular Injury PROTECT
Hip Arthroplasty MetaADEDB
Hip Fracture MetaADEDB
Hospitalisation MetaADEDB
Hostility MetaADEDB
Humerus Fracture MetaADEDB
Hypercoagulation MetaADEDB
Hyperglycaemia ADReCS
Hyperglycaemic Hyperosmolar Nonketotic Syndrome MetaADEDB
Hyperhidrosis PROTECT
Hyperlipaemia MetaADEDB
Hypersensitivity PROTECT
Hypertension ADReCS
Hypertensive Emergency MetaADEDB
Hypertonia MetaADEDB
Hypertrichosis MetaADEDB
Hypoaesthesia ADReCS
Hypoalbuminaemia MetaADEDB
Hypoglycaemia ADReCS
Hypoglycaemia Neonatal MetaADEDB
Hypoglycaemic Unconsciousness MetaADEDB
Hypokinesia MetaADEDB
Hypophagia MetaADEDB
Hypotension Orthostatic MetaADEDB
Hypothyroid MetaADEDB
Hypouricaemia MetaADEDB
Ild MetaADEDB
Ill-Defined Disorder MetaADEDB
Immobile MetaADEDB
Immobilisation Prolonged MetaADEDB
Immune System Disorder MetaADEDB
Impaired Self-Care MetaADEDB
Impingement Syndrome MetaADEDB
Implantable Defibrillator Malfunction MetaADEDB
Increased Appetite PROTECT
Increased Platelet Count MetaADEDB
Increased White Blood Cell Count MetaADEDB
Infected Cyst MetaADEDB
Infection MetaADEDB
Infection Susceptibility Increased MetaADEDB
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Infusion Site Mobility Decreased MetaADEDB
Injection Site Induration MetaADEDB
Insomnia PROTECT
Insulin Resistance MetaADEDB
Intentional Misuse MetaADEDB
International Normalised Ratio Fluctuation MetaADEDB
Intervertebral Disc Degeneration MetaADEDB
Intestinal Functional Disorder MetaADEDB
Ischaemia ADReCS
Ischias MetaADEDB
Joint Injury MetaADEDB
Kidney Infection MetaADEDB
Klebsiella Infection MetaADEDB
Laryngeal Disorder MetaADEDB
Left Ventricular Hypertrophy MetaADEDB
Leg Amputation ADReCS
Leukocyturia MetaADEDB
Life Expectancy Shortened MetaADEDB
Light Sensitivity MetaADEDB
Limb Injury MetaADEDB
Liver Function Test Abnormal ADReCS
Localised Oedema MetaADEDB
Lower Gastrointestinal Haemorrhage MetaADEDB
Lower Limb Fracture MetaADEDB
Lymph Node Abscess MetaADEDB
Lymphangitis MetaADEDB
Lymphoma MetaADEDB
Macular Ischaemia MetaADEDB
Macular Oedema PROTECT
Major Depression MetaADEDB
Markedly Reduced Dietary Intake MetaADEDB
Mean Platelet Volume MetaADEDB
Mediastinal Tumor MetaADEDB
Mental Disorder MetaADEDB
Mental Status Changes MetaADEDB
Metastases To Lymph Nodes MetaADEDB
Mitral Valve Calcification MetaADEDB
Mitral Valve Stenosis MetaADEDB
Mouth Pain MetaADEDB
Mucosa Vesicle MetaADEDB
Multi-Organ Disorder MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Pain MetaADEDB
Myalgia ADReCS
Myelopathy MetaADEDB
Myocardial Ischaemia ADReCS
Nasal Congestion MetaADEDB
Nasal Discomfort MetaADEDB
Nasal Dryness MetaADEDB
Nasal Septal Operation MetaADEDB
Nasal Ulcer MetaADEDB
Nausea MetaADEDB
Necrotising Colitis MetaADEDB
Neoplasm ADReCS
Neoplasm Malignant ADReCS
Nephrogenic Diabetes Insipidus MetaADEDB
Nephrogenic Fibrosing Dermopathy MetaADEDB
Nervous Tension MetaADEDB
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Obsessive-Compulsive Personality Disorder MetaADEDB
Occult Blood MetaADEDB
Occult Blood Positive MetaADEDB
Oedema ADReCS
Oesophageal Dilatation MetaADEDB
Oestrogen Receptor Assay Positive MetaADEDB
Off Label Use MetaADEDB
Oophorectomy Bilateral MetaADEDB
Oral Herpes MetaADEDB
Osteochondrosis MetaADEDB
Pain In Extremity ADReCS
Pallor MetaADEDB
Palpitation MetaADEDB
Pancreatic Neoplasm MetaADEDB
Pancreatitis MetaADEDB
Paranoia MetaADEDB
Parotid Gland Enlargement MetaADEDB
Pemphigus MetaADEDB
Periodontal Operation MetaADEDB
Peripheral Revascularisation ADReCS
Peritonitis Bacterial MetaADEDB
Personality Disorder MetaADEDB
Pharyngeal Inflammation MetaADEDB
Pharyngeal Lesion MetaADEDB
Pharyngitis ADReCS
Phlebitis MetaADEDB
Phlebothrombosis MetaADEDB
Physical Disability MetaADEDB
Pitting Edema SIDER
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia Fungal MetaADEDB
Polycystic Ovaries MetaADEDB
Polymyalgia Rheumatica MetaADEDB
Polyneuropathy MetaADEDB
Proctalgia MetaADEDB
Progesterone Receptor Assay MetaADEDB
Prostate Infection MetaADEDB
Proteinuria PROTECT
Pseudomonal Sepsis MetaADEDB
Pulmonary Hypertension MetaADEDB
Pulmonary Valve Incompetence MetaADEDB
Rectal Tenesmus MetaADEDB
Refusal Of Treatment By Patient MetaADEDB
Renal Cyst MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Tract Infection ADReCS
Scleroderma MetaADEDB
Sepsis Syndrome MetaADEDB
Serratia Sepsis MetaADEDB
Shoplifting MetaADEDB
Sinoatrial Block MetaADEDB
Sinus Bradycardia MetaADEDB
Sinus Headache MetaADEDB
Sinus Polyp MetaADEDB
Sinusitis ADReCS
Skin Laceration MetaADEDB
Sleep Apnea MetaADEDB
Small Intestinal Obstruction MetaADEDB
Social Avoidant Behaviour ADReCS
Speech Disorder MetaADEDB
Spinal Cord Compression MetaADEDB
Spondylolisthesis MetaADEDB
Staphylococcal Abscess MetaADEDB
Staphylococcal Infection MetaADEDB
Stent Placement MetaADEDB
Stereotypy MetaADEDB
Stroke ADReCS
Subcutaneous Nodule MetaADEDB
Supraventricular Tachycardia MetaADEDB
Synovial Cyst MetaADEDB
Temperature Intolerance MetaADEDB
Therapeutic Response Unexpected MetaADEDB
Throat Cancer MetaADEDB
Throat Tightness MetaADEDB
Tinea Cruris MetaADEDB
Tongue Black Hairy MetaADEDB
Tongue Discolouration MetaADEDB
Tonsillar Disorder MetaADEDB
Tonsillitis MetaADEDB
Tooth Disorder ADReCS
Tooth Infection MetaADEDB
Tooth Repair MetaADEDB
Transplant Failure MetaADEDB
Treatment Failure MetaADEDB
Trichorrhexis MetaADEDB
Ulna Fracture MetaADEDB
Unresponsive To Stimuli MetaADEDB
Upper Respiratory Tract Infection ADReCS
Urinary Tract Infection ADReCS
Urinary Tract Infection Bacterial MetaADEDB
Urine Abnormality MetaADEDB
Vascular Calcification MetaADEDB
Vascular Graft Occlusion MetaADEDB
Venoocclusive Liver Disease MetaADEDB
Venous Insufficiency MetaADEDB
Venous Stasis MetaADEDB
Venous Thrombosis Limb MetaADEDB
Vertigo PROTECT
Viral Upper Respiratory Tract Infection MetaADEDB
Visual Acuity Reduced ADReCS
Visual Brightness MetaADEDB
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vocal Cord Paralysis MetaADEDB
Volvulus MetaADEDB
Weight Gain MetaADEDB
Weight Increased ADReCS
Wheeze MetaADEDB
Withdrawn SIDER
Wound Infection Staphylococcal MetaADEDB
Wound Necrosis MetaADEDB
Xerosis MetaADEDB

InAADR: Drug-Protein-ADRs database