| Drug Name: | Phenylbutazone (50-33-9) |
|---|---|
| PubChem ID: | 4781 |
| SMILES: | CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3 |
| InchiKey: | VYMDGNCVAMGZFE-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Anti-Inflammatory Agents, Antirheumatic Agents, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 308.381 |
| LogP | : | 3.7878 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 40.62 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Acetylsalicylic acid (50-78-2) | Disorder Gastrointestinal | Antagonistic | Not understood | Suppression of salicylate-induced uricosuria by phenylbutazone |
| Indomethacin (53-86-1) | Renal Impairment | Additive | The damaging effects of the NSAIDs on the gut appear to be additive | Exacerbation of phenylbutazone-related renal failure by indomethacin |
| Methotrexate (59-05-2) | Bone Marrow Depression | Synergistic | The NSAIDs as a group inhibit the synthesis of the prostaglandins (PGE2) resulting in a fall in renal perfusion, which could lead to a rise in serum methotrexate levels | Drug interaction in psoriasis |
| Methotrexate (59-05-2) | Septicaemia | Synergistic | The NSAIDs as a group inhibit the synthesis of the prostaglandins (PGE2) resulting in a fall in renal perfusion, which could lead to a rise in serum methotrexate levels | Drug interaction in psoriasis |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category