| Drug Name: | Omeprazole (73590-58-6) |
|---|---|
| PubChem ID: | 4594 |
| SMILES: | CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC |
| InchiKey: | SUBDBMMJDZJVOS-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-Ulcer Agents, Enzyme Inhibitors, Gastrointestinal Agents, Proton Pump Inhibitors |
| Molecular Weight (dalton) | : | 345.424 |
| LogP | : | 2.89974 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 77.1 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Carbamazepine (298-46-4) | Reduction In Carbamazepine Serum Levels | Synergistic | Omeprazole may inhibit the oxidative metabolism of single doses of carbamazepine. However, when carbamazepine is taken continuously it induces its own metabolism by the cytochrome P450 isoenzyme CYP3A4, thereby possibly opposing the effects of this interaction | Effect of Multiple Dose Omeprazole on the Pharmacokinetics of Carbamazepine |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Block Gastric Acid Secretion | Potassium-transporting ATPase (P54707) | Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase [ ADR Type 1 ] | Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category