This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Development Of Tolerance | Choline O-acetyltransferase (P28329) | A small change in hippocampal choline acetyltransferase activity may have occurred@suggesting that tolerance to nicotine is regulated by genetic factors and that changes in brain nicotinic receptor numbers are to explain the development of tolerance. [ ADR Type 3 ] | Nicotine-induced tolerance and receptor changes in four mouse strains
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| Disintegration Of Cells | Collagen (P02452) | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Disrupted Cell Architecture | Collagen (P02452) | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Extracellular Matrix | Collagen (P02452) | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Reduced Cell Proliferation | Collagen (P02452) | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Tardive Dyskinesia | Cytochrome P450 1A2 (P05177) | A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene is associated with tardive dyskinesia in schizophrenia. [ ADR Type 3 ] | A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia
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| Ulcerative Colitis | Interleukin-8 (P10145) | Transdermal nicotine decreases mucosal IL-8 expression@which lead to ulcerative colitis [ ADR Type 5 ] | Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis Inflamm Bowel Dis 1
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