| Drug Name: | Naproxen (22204-53-1) |
|---|---|
| PubChem ID: | 156391 |
| SMILES: | C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O |
| InchiKey: | CMWTZPSULFXXJA-VIFPVBQESA-N |
| Therapeutic Category: | Analgesics, Anti-Inflammatory Agents, Antirheumatic Agents, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Gout Suppressants, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 230.263 |
| LogP | : | 3.0365 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 46.53 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Clopidogrel (113665-84-2) | Gastrointestinal Bleeding | Synergistic | Unclear | Effect of clopidogrel on naproxen-induced gastrointestinal blood loss in healthy volunteers |
| Amoxicillin (26787-78-0) | Acute Interstitial Nephritis | Antagonistic | Not understood | Acute interstitial nephritis with nephrotic syndrome after intake of naproxen and amoxycillin |
| Auranofin (34031-32-8) | Pneumonitis | Antagonistic | Not Established | Gold-naproxen pneumonitis A toxic drug interaction |
| Ciprofloxacin (85721-33-1) | Neurotoxicity | Antagonistic | Not fully understood Experiments in mice have shown that quinolones competitively inhibit the binding of gamma-amino butyric acid (GABA) to its receptors the NSAID simply lowers the amount of quinolone needed to precipitate convulsions in already susceptible individuals | Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category