| Drug Name: | Methadone (76-99-3) |
|---|---|
| PubChem ID: | 4095 |
| SMILES: | CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 |
| InchiKey: | USSIQXCVUWKGNF-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Antitussive Agents, Central Nervous System Agents, Central Nervous System Depressants, Narcotics, Peripheral Nervous System Agents, Respiratory System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 309.453 |
| LogP | : | 4.292 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 20.31 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Ciprofloxacin (85721-33-1) | Respiratory Depression | Additive | The cytochrome P450 isoenzymes CYP1A2, CYP2D6 and CYP3A4 are involved in the metabolism of methadone. Ciprofloxacin is a potent inhibitor of CYP1A2 and possibly has some effect on CYP3A4. It is therefore probable that the confusion and sedation seen in the patient were due to the inhibition of methadone metabolism | Methadone, ciprofloxacin, and adverse drug reactions |
| Cocaine (50-36-2) | Torsade De Pointes | Additive | Not Known | Cocaine-related torsade de pointes in a methadone maintenance patient |
| Temazepam (846-50-4) | Sudden Death | Additive | Not Known | Sudden death in an adult taking methadone: lessons for general practice |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category