| Drug Name: | Mesalazine (89-57-6) |
|---|---|
| PubChem ID: | 4075 |
| SMILES: | C1=CC(=C(C=C1N)C(=O)O)O |
| InchiKey: | KBOPZPXVLCULAV-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Anti-Inflammatory Agents, Antirheumatic Agents, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 153.137 |
| LogP | : | 0.6726 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 83.55 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Azathioprine (446-86-6) | Pancytopenia | Synergistic | The metabolism of azathioprine and mercaptopurine depends on S-methylation by thiopurine methyltransferase (TPMT) and oxidation by xanthine oxidase. An in vitro study using recombinant TPMT found that both sulfasalazine and its metabolites inhibit the activity of TPMT. | Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category