| Drug Name: | Lovastatin (75330-75-5) |
|---|---|
| PubChem ID: | 53232 |
| SMILES: | CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C |
| InchiKey: | PCZOHLXUXFIOCF-BXMDZJJMSA-N |
| Therapeutic Category: | Anticholesteremic Agents, Antimetabolites, Enzyme Inhibitors, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypolipidemic Agents, Lipid Regulating Agents |
| Molecular Weight (dalton) | : | 404.547 |
| LogP | : | 4.1955 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 72.83 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Apoptosis | BAX protein (Q07815) | Since immunoelectron microscopy showed translocation of Bax to the mitochondria in lovastatin-treated cells@ lovastatin-induced apoptosis may@ therefore@ ultimately dependent on Bax induction of cytochrome c release. [ ADR Type 5 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism |
| Apoptosis | Caspase-3 (P42574) | Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism |
| Apoptosis | Caspase-8 (Q14790) | Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism |
| Apoptosis | Caspase-9 (P55211) | Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism |
| Apoptosis | cytochrome c (P00009) | Since immunoelectron microscopy showed translocation of Bax to the mitochondria in lovastatin-treated cells, lovastatin-induced apoptosis may, therefore, ultimately dependent on Bax induction of cytochrome c release [ ADR Type 5 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism |
| Hepatotoxicity | Alanine aminotransferase (P24298) | Depletion of a nonsterol metabolite(s) of mevalonate critical for cell viability@which leads to lovastatin-induced hepatotoxicity. [ ADR Type 2 ] | Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits |
| Human Natural Killer (Nk) Cell Cytotoxicity | Interleukin-2 (P60568) | The activation of human natural killer (NK) cell cytotoxicity by interleukin 2 (IL-2) [ ADR Type 5 ] | Reversal of lovastatin-mediated inhibition of natural killer cell cytotoxicity by interleukin 2 |
| Induce Cataract Formation | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (P04035) | Treatment with high doses of lovastatin has been reported to induce cataract formation in dogs through inhibition of HMG-Co A reductase. [ ADR Type 1 ] | Absence of cataractogenic effect of lovastatin (Mevinacor) so far |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|---|---|
| Grapefruit Juice | Acute Renal Failure | Food–drug interaction: grapefruit juice augments drug bioavailabilityFmechanism, extent and relevance |
| Grapefruit Juice | Rhabdomyolysis | Food–drug interaction: grapefruit juice augments drug bioavailabilityFmechanism, extent and relevance |
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category