| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Apoptosis | BAX protein (Q07815) | Since immunoelectron microscopy showed translocation of Bax to the mitochondria in lovastatin-treated cells@ lovastatin-induced apoptosis may@ therefore@ ultimately dependent on Bax induction of cytochrome c release. [ ADR Type 5 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism
|
| Apoptosis | Caspase-3 (P42574) | Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism
|
| Apoptosis | Caspase-8 (Q14790) | Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism
|
| Apoptosis | Caspase-9 (P55211) | Consistent with initiation of apoptosis@ cellular caspase-8@ caspase-9 and caspase-3 activities were elevated in lovastatin-treated cells. [ ADR Type 2 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism
|
| Apoptosis | cytochrome c (P00009) | Since immunoelectron microscopy showed translocation of Bax to the mitochondria in lovastatin-treated cells, lovastatin-induced apoptosis may, therefore, ultimately dependent on Bax induction of cytochrome c release [ ADR Type 5 ] | Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism
|
| Hepatotoxicity | Alanine aminotransferase (P24298) | Depletion of a nonsterol metabolite(s) of mevalonate critical for cell viability@which leads to lovastatin-induced hepatotoxicity. [ ADR Type 2 ] | Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits
|
| Human Natural Killer (Nk) Cell Cytotoxicity | Interleukin-2 (P60568) | The activation of human natural killer (NK) cell cytotoxicity by interleukin 2 (IL-2) [ ADR Type 5 ] | Reversal of lovastatin-mediated inhibition of natural killer cell cytotoxicity by interleukin 2
|
| Induce Cataract Formation | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (P04035) | Treatment with high doses of lovastatin has been reported to induce cataract formation in dogs through inhibition of HMG-Co A reductase. [ ADR Type 1 ] | Absence of cataractogenic effect of lovastatin (Mevinacor) so far
|