| Drug Name: | Lopinavir (192725-17-0) |
|---|---|
| PubChem ID: | 52987589 |
| SMILES: | CC1=C(C(=CC=C1)C)OCC(=O)N[C@@H](CC2=CC=CC=C2)[C@H](C[C@@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)N4CCCNC4=O)O |
| InchiKey: | KJHKTHWMRKYKJE-AZWAZIRRSA-N |
| Therapeutic Category: | Anti-HIV Agents, Anti-Infective Agents, Anti-Retroviral Agents, Antiviral Agents, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Enzyme Inhibitors, HIV Protease Inhibitors, Protease Inhibitors |
| Molecular Weight (dalton) | : | 628.814 |
| LogP | : | 4.32814 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 4 |
| Total Polar Surface Area | : | 120 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Paclitaxel (33069-62-4) | Myelosuppression | Synergistic | Paclitaxel is metabolised by the cytochrome P450 enzymes CYP2C8 and CYP3A4.indinavir are known to inhibit CYP3A4 enzyme | Recrudescent Kaposi's Sarcoma After Initiation of HAART: A Manifestation of Immune Reconstitution Syndrome |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category