| Drug Name: | Ketoprofen (22071-15-4) |
|---|---|
| PubChem ID: | 3825 |
| SMILES: | CC(C1=CC=CC(=C1)C(=O)C2=CC=CC=C2)C(=O)O |
| InchiKey: | DKYWVDODHFEZIM-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Anti-Inflammatory Agents, Antirheumatic Agents, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 254.285 |
| LogP | : | 3.1057 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 54.37 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Intestinal Toxicity | Glutathione reductase (P00390) | A significant increase of tumor necrosis factor-alpha production and decreases in glutathione levels and glutathione reductase activity after treatment of the racemate and (R)-(-)-ketoprofen,suggesting induced intestinal toxicity could be correlated with a reduced oxidative damage characterized not only by a lack of changes in glutathione reductase activity but also by an absence of up-regulation of tumor necrosis factor-alpha production in intestinal mucosa. [ ADR Type 2 ] | Mechanisms involved in the attenuation of intestinal toxicity induced by (S)-(+)-ketoprofen in re-fed rats |
| Intestinal Toxicity | Tumor necrosis factor precursor (P01375) | A significant increase of tumor necrosis factor-alpha production and decreases in glutathione levels and glutathione reductase activity after treatment of the racemate and (R)-(-)-ketoprofen,suggesting induced intestinal toxicity could be correlated with a reduced oxidative damage characterized not only by a lack of changes in glutathione reductase activity but also by an absence of up-regulation of tumor necrosis factor-alpha production in intestinal mucosa. [ ADR Type 2 ] | Mechanisms involved in the attenuation of intestinal toxicity induced by (S)-(+)-ketoprofen in re-fed rats |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category