InAADR

Drug Information

Drug Name: Ivermectin (70288-86-7)
PubChem ID: 122172888
SMILES: CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4CO[C@H]5[C@@]4(C(C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)C)C
InchiKey: AZSNMRSAGSSBNP-RDKIRRGNSA-N
Therapeutic Category: Anti-Infective Agents, Antiparasitic Agents, Insecticides, Pesticides

Computed Drug Properties

Molecular Weight (dalton): 875.106
LogP: 5.6014
Ring Count: 0
Hydrogen Bond Acceptor Count: 14
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 170.06

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Cytotoxicity Canalicular multispecific organic anion transporter (O15438) Ivermectin efficiently inhibites the fully activated ATPase of MRP3 with respective IC50 values of 40 ? 20 ?M, thus increases the Cytotoxicity of verapamil [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells
Cytotoxicity Multidrug resistance protein 1 (P08183) Ivermectin induces a clear inhibition on P-glycoprotein (PGP) basal ATPase activity@ thus increases the Cytotoxicity of verapamil [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells
Cytotoxicity Multidrug resistance-associated protein (P33527) Ivermectin efficiently inhibites the fully activated ATPase of MRP1 with respective IC50 values of 9 ? 4?M@ thus increases the Cytotoxicity of benzbromarone. [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells
Cytotoxicity Multidrug resistance-associated protein (Q92887) Ivermectin efficiently inhibites the fully activated ATPase of MRP2 with respective IC50 values of 18 ? 5 ?M@ thus increases the Cytotoxicity of verapamil [ ADR Type 4 ] P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Distension ADReCS
Abdominal Pain ADReCS
Abdominal Tenderness MetaADEDB
Abnormal Behaviour MetaADEDB
Abnormal Eeg MetaADEDB
Abnormal Gait MetaADEDB
Abnormal Sensation In Eye ADReCS
Abortion Induced MetaADEDB
Accident MetaADEDB
Accidental Exposure MetaADEDB
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acute Brain Syndrome MetaADEDB
Acute Glomerulonephritis MetaADEDB
Adverse Drug Effect MetaADEDB
Adverse Event MetaADEDB
Agitated MetaADEDB
Agraphia MetaADEDB
Alanine Aminotransferase Increased ADReCS
Alcohol Consumption MetaADEDB
Alcoholic Intoxication MetaADEDB
Alpha Haemolytic Streptococcal Infection MetaADEDB
Anaemia ADReCS
Anaesthesia MetaADEDB
Anal Sphincter Atony MetaADEDB
Anemia Aplastic MetaADEDB
Angioedema MetaADEDB
Anorexia ADReCS
Anterior Uveitis SIDER
Anuria MetaADEDB
Aphonia MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthralgia ADReCS
Ascaridida Infections MetaADEDB
Aspiration Pneumonia MetaADEDB
Asthenia ADReCS
Asthma ADReCS
Ataxia MetaADEDB
Back Ache MetaADEDB
Bacterial Infection MetaADEDB
Bacterial Toxaemia MetaADEDB
Bedridden MetaADEDB
Biopsy Kidney MetaADEDB
Bladder Distension MetaADEDB
Bladder Retention MetaADEDB
Bleb MetaADEDB
Blighted Ovum MetaADEDB
Blindness ADReCS
Blindness Unilateral MetaADEDB
Blood Bilirubin Increased ADReCS
Blood Calcium Increased MetaADEDB
Blood Fibrinogen Increased MetaADEDB
Blood Pressure Abnormal MetaADEDB
Blood Smear Test Abnormal MetaADEDB
Blurred Vision MetaADEDB
Body Fat Disorder MetaADEDB
Body Temperature MetaADEDB
Body Temperature Increased ADReCS
Bone Marrow Disorder MetaADEDB
Bone Marrow Toxicity MetaADEDB
Brain Oedema MetaADEDB
Bronchoalveolar Lavage MetaADEDB
Bronchopneumonia MetaADEDB
Bulbar Palsy MetaADEDB
Burning Sensation ADReCS
Candida Infection MetaADEDB
Cardiac Failure Chronic MetaADEDB
Cardiogenic Shock MetaADEDB
Cerebral Atrophy MetaADEDB
Cerebral Disorder MetaADEDB
Cervicalgia MetaADEDB
Cheilitis MetaADEDB
Chest Discomfort ADReCS
Chest Infection MetaADEDB
Chest Pain ADReCS
Chill MetaADEDB
Chorioretinitis ADReCS
Choroiditis ADReCS
Cns Ventriculitis MetaADEDB
Coagulation Time Prolonged MetaADEDB
Cold Extremities MetaADEDB
Coma MetaADEDB
Confabulation MetaADEDB
Conjunctival Deposit MetaADEDB
Conjunctival Haemorrhage ADReCS
Conjunctival Hyperaemia MetaADEDB
Conjunctivitis ADReCS
Constipation ADReCS
Convulsion ADReCS
Cough MetaADEDB
Crackles Lung MetaADEDB
Cryoglobulinaemia MetaADEDB
Csf Protein MetaADEDB
Csf Protein Increased MetaADEDB
Dandruff ADReCS
Deafness MetaADEDB
Death MetaADEDB
Decreased Appetite ADReCS
Decubitus Ulcer MetaADEDB
Deglutition Disorder MetaADEDB
Delirium Tremens MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Dermatitis ADReCS
Dermatitis Exfoliative MetaADEDB
Diabetes Insipidus MetaADEDB
Diabetic Hyperosmolar Coma MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diet Refusal MetaADEDB
Difficulty In Walking MetaADEDB
Dirofilariasis MetaADEDB
Discomfort ADReCS
Disorder Of Globe MetaADEDB
Distention SIDER
Dizziness ADReCS
Dog Diseases MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Skin ADReCS
Dysprosody MetaADEDB
Dysstasia MetaADEDB
Ear Infection MetaADEDB
Eating Disorder MetaADEDB
Edema Extremities MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Encephalitis MetaADEDB
Encephalopathy MetaADEDB
Encephalopathy Hypertensive MetaADEDB
Enlarged Liver MetaADEDB
Enophthalmos MetaADEDB
Enterobiasis MetaADEDB
Enterococcal Infection MetaADEDB
Eosinophilia ADReCS
Erythema Of Eyelid MetaADEDB
Escherichia Bacteraemia MetaADEDB
Escherichia Infection MetaADEDB
Expressive Language Disorder MetaADEDB
Eye Disorder ADReCS
Eye Irritation ADReCS
Eye Pruritus MetaADEDB
Eye Redness MetaADEDB
Eyelid Oedema ADReCS
Face Oedema ADReCS
Faecal Incontinence MetaADEDB
Fatigue ADReCS
Feeding Disorder MetaADEDB
Feeling Cold MetaADEDB
Fever MetaADEDB
Fibrin Degradation Products Increased MetaADEDB
Filariasis MetaADEDB
Gastrointestinal Diseases MetaADEDB
Gastrointestinal Motility Disorder MetaADEDB
Gastrointestinal Pain ADReCS
General Symptom MetaADEDB
Genital Ulceration MetaADEDB
Glasgow Coma Scale MetaADEDB
Glossitis MetaADEDB
Haemoglobin Increased ADReCS
Headache ADReCS
Heart Rate Increased MetaADEDB
Helminthic Infection MetaADEDB
Hematoma Subdural MetaADEDB
Hematuria MetaADEDB
Hemiplegia MetaADEDB
Hepatic Enzyme Increased ADReCS
Hepatitis ADReCS
Herpes Simplex MetaADEDB
Hiccough MetaADEDB
Horse Diseases MetaADEDB
Hydrocephalus MetaADEDB
Hyperreflexia MetaADEDB
Hypertrophy ADReCS
Hypervitaminosis MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Hypotonia MetaADEDB
Inappropriate Schedule Of Drug Administration MetaADEDB
Incoherent MetaADEDB
Incontinence MetaADEDB
Incorrect Route Of Drug Administration MetaADEDB
Iridocyclitis ADReCS
Itch MetaADEDB
Jejunal Ulcer MetaADEDB
Joint Stiffness MetaADEDB
Keratitis ADReCS
Klebsiella Sepsis MetaADEDB
Lacrimation Increased MetaADEDB
Leukoencephalopathy MetaADEDB
Leukopenia ADReCS
Light Sensitivity MetaADEDB
Limb Discomfort MetaADEDB
Logorrhoea MetaADEDB
Loiasis MetaADEDB
Lymph Node Pain ADReCS
Lymphadenopathy ADReCS
Lymphadenopathy Axillary SIDER
Lymphadenopathy Cervical SIDER
Malaria MetaADEDB
Marasmus MetaADEDB
Mazzotti Reaction MetaADEDB
Meningitides MetaADEDB
Meningitis Bacterial MetaADEDB
Mental Status Changes MetaADEDB
Monkey Diseases MetaADEDB
Monoparesis MetaADEDB
Mouth Pain MetaADEDB
Muscle Rupture MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Disorder MetaADEDB
Musculoskeletal Stiffness MetaADEDB
Mutism MetaADEDB
Myalgia ADReCS
Myelitis MetaADEDB
Myeloid Maturation Arrest MetaADEDB
Nausea ADReCS
Necrolysis Epidermal SIDER
Nematode Infections MetaADEDB
Nephrolithiasis MetaADEDB
Nuchal Rigidity MetaADEDB
Ocular Hyperaemia ADReCS
Ocular Icterus MetaADEDB
Odynophagia MetaADEDB
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophageal Candidiasis MetaADEDB
Onchocerciasis MetaADEDB
Orthostatic Hypotension ADReCS
Ototoxicity MetaADEDB
Oxyuriasis MetaADEDB
Pain ADReCS
Palpitation MetaADEDB
Papillary Necrosis MetaADEDB
Paraesthesia ADReCS
Paraparesis MetaADEDB
Parasitic Diseases MetaADEDB
Parasitic Infection Intestinal MetaADEDB
Penile Swelling MetaADEDB
Physical Disability MetaADEDB
Pitting Oedema MetaADEDB
Prescribed Overdose MetaADEDB
Proteinuria MetaADEDB
Proteus Infection MetaADEDB
Pruritus ADReCS
Pruritus Generalised MetaADEDB
Pulmonary Embolism MetaADEDB
Pulse Abnormal MetaADEDB
Punctate Keratitis ADReCS
Purulent Discharge MetaADEDB
Pyrexia ADReCS
Rash ADReCS
Rash Papular ADReCS
Red Blood Cell Count Abnormal MetaADEDB
Relapsing Fever MetaADEDB
Renal Insufficiency MetaADEDB
Renal Tubular Disorder MetaADEDB
Respiratory Rate Increased MetaADEDB
Respiratory Tract Congestion MetaADEDB
Restrictive Cardiomyopathy MetaADEDB
Scrotal Swelling MetaADEDB
Seizures MetaADEDB
Sepsis Syndrome MetaADEDB
Skin Desquamation MetaADEDB
Skin Lesion MetaADEDB
Skin Oedema ADReCS
Somatic Delusion MetaADEDB
Somnolence ADReCS
Speech Disorder MetaADEDB
Speech Disorder Developmental MetaADEDB
Spinning Sensation MetaADEDB
Stevens-Johnson Syndrome ADReCS
Strongyle Infections Equine MetaADEDB
Strongyloidiasis MetaADEDB
Sudden Death MetaADEDB
Superinfection Bacterial MetaADEDB
Synovitis ADReCS
Tachycardia ADReCS
Tenderness ADReCS
Tongue Dry MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Tremor ADReCS
Umbilical Hernia MetaADEDB
Urine Colour Abnormal MetaADEDB
Urine Odour Abnormal MetaADEDB
Urticaria ADReCS
Urticaria Chronic MetaADEDB
Uveitis ADReCS
Vertigo ADReCS
Vertigo Positional MetaADEDB
Vital Capacity Decreased MetaADEDB
Vomiting ADReCS
White Blood Cell Count Decreased ADReCS

InAADR: Drug-Protein-ADRs database