InAADR

Drug Information

Drug Name: Halothane (151-67-7)
PubChem ID: 3562
SMILES: C(C(F)(F)F)(Cl)Br
InchiKey: BCQZXOMGPXTTIC-UHFFFAOYSA-N
Therapeutic Category: Anesthetics, Central Nervous System Agents, Central Nervous System Depressants

Computed Drug Properties

Molecular Weight (dalton): 197.381
LogP: 2.5085
Ring Count: 0
Hydrogen Bond Acceptor Count: 0
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 0

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Amiodarone (1951-25-3) Vasodilator Effects Additive In vitro and in vivo studies in animals suggest that amiodarone has additive cardiodepressant and vasodilator effects with volatile anaesthetics such as halothane, enflurane and isoflurane Should oral amiodarone be used for sustained ventricular tachycardia in patients requiring open-heart surgery?

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Hepatotoxicity Alanine aminotransferase (P24298) Increases in serum enzyme activities of the alanine aminotransferase (GPT) and the sorbitol dehydrogenase (SDH) were evident immediately following exposure and were six-fold higher@which leads to halothane hepatotoxicity [ ADR Type 2 ] Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model
Hepatotoxicity CYP2A6 (P11509) Both P450 2E1 and P450 2A6 participate in human halothane metabolism@ and that P450 2E1 is the predominant catalytic isoform
Hepatotoxicity Cytochrome P450 2E1 (P05181) Both P450 2E1 and P450 2A6 participate in human halothane metabolism@ and that P450 2E1 is the predominant catalytic isoform. [ ADR Type 2 ] Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro
Hepatotoxicity Sorbitol dehydrogenase (Q00796) Increases in serum enzyme activities of the alanine aminotransferase (GPT) and the sorbitol dehydrogenase (SDH) were evident immediately following exposure and were six-fold higher@which leads to halothane hepatotoxicity. [ ADR Type 2 ] Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model
Liver Cell Necrosisand Mitoses Alanine aminotransferase (P24298) Focal liver cell necrosisand occasional mitoses [ ADR Type 2 ] Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure
Liver Cells Fatty Change Alanine aminotransferase (P24298) Many liver cells showed fatty change. [ ADR Type 2 ] Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure
Lobular Disarray Alanine aminotransferase (P24298) Considerable lobular disarray [ ADR Type 2 ] Hepatic injury in rats due to prolonged sub-anaesthetic halothane exposure
Porcine Stress Syndrome Alanine aminotransferase (P24298) Serum alanine aminotransferase increased in only those animals sacrificed at 24 hrs@ which leads to halothane induced porcine stress syndrome [ ADR Type 1 ] Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abnormalities Drug-Induced MetaADEDB
Acidosis MetaADEDB
Acute Kidney Injury MetaADEDB
Anemia MetaADEDB
Anuria MetaADEDB
Apnea MetaADEDB
Arrhythmia ADReCS
Arrhythmias Cardiac MetaADEDB
Arterial Occlusive Diseases MetaADEDB
Arthralgia MetaADEDB
Asphyxia MetaADEDB
Asthma MetaADEDB
Azotemia MetaADEDB
Bradycardia MetaADEDB
Brain Diseases MetaADEDB
Brain Injuries MetaADEDB
Cardiac Arrest ADReCS
Cardiac Output High MetaADEDB
Cardiac Output Low MetaADEDB
Chills ADReCS
Cholestasis MetaADEDB
Death Sudden MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Eosinophilia MetaADEDB
Fatty Liver MetaADEDB
Fetal Diseases MetaADEDB
Fever MetaADEDB
Granuloma MetaADEDB
Headache MetaADEDB
Heart Arrest MetaADEDB
Heart Block MetaADEDB
Heart Diseases MetaADEDB
Heart Failure MetaADEDB
Hepatic Encephalopathy MetaADEDB
Hepatic Necrosis ADReCS
Hepatitis MetaADEDB
Hepatitis Chronic MetaADEDB
Hyperalgesia MetaADEDB
Hyperemia MetaADEDB
Hyperkalemia MetaADEDB
Hyperpyrexia ADReCS
Hypertension MetaADEDB
Hypotension ADReCS
Infarction Middle Cerebral Artery MetaADEDB
Jaundice MetaADEDB
Kidney Diseases MetaADEDB
Laryngismus MetaADEDB
Liver Cirrhosis MetaADEDB
Liver Diseases MetaADEDB
Liver Failure MetaADEDB
Liver Failure Acute MetaADEDB
Malignant Hyperthermia MetaADEDB
Massive Hepatic Necrosis MetaADEDB
Movement Disorders MetaADEDB
Muscle Rigidity MetaADEDB
Muscular Diseases MetaADEDB
Myocardial Ischemia MetaADEDB
Myoglobinuria MetaADEDB
Nausea ADReCS
Necrosis ADReCS
Neutropenia MetaADEDB
Oliguria MetaADEDB
Pain MetaADEDB
Postoperative Complications MetaADEDB
Prenatal Exposure Delayed Effects MetaADEDB
Quadriplegia MetaADEDB
Renal Insufficiency MetaADEDB
Respiratory Arrest ADReCS
Respiratory Insufficiency MetaADEDB
Rhabdomyolysis MetaADEDB
Seizures MetaADEDB
Shivering ADReCS
Sinus Arrest Cardiac MetaADEDB
Somatosensory Disorders MetaADEDB
Status Asthmaticus MetaADEDB
Status Epilepticus MetaADEDB
Tachycardia MetaADEDB
Tachycardia Ventricular MetaADEDB
Thrombosis MetaADEDB
Torsades De Pointes MetaADEDB
Trismus MetaADEDB
Ventricular Dysfunction Left MetaADEDB
Ventricular Dysfunction Right MetaADEDB
Ventricular Fibrillation MetaADEDB
Vomiting ADReCS

InAADR: Drug-Protein-ADRs database