| Drug Name: | Fosinopril (98048-97-6) |
|---|---|
| PubChem ID: | 45357796 |
| SMILES: | CCC(=O)O[C@H](C(C)C)O[P@@](=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)O)C3CCCCC3 |
| InchiKey: | BIDNLKIUORFRQP-FLODCBCLSA-N |
| Therapeutic Category: | Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cardiovascular Agents, Enzyme Inhibitors, Protease Inhibitors |
| Molecular Weight (dalton) | : | 563.672 |
| LogP | : | 6.1213 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 110.21 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Acenocoumarol (152-72-7) | Melaena | Additive | Unknown | Plausible pharmacologic interaction between fosinopril and acenocoumarol |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Bradycardia | Angiotensin-converting enzyme precursor (P12821) | Renoprotective effects@ blood-pressure reduction@ reduction in left ventricular mass@ endothelial function. [ ADR Type 1 ] | Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients-- interaction with ACE insertion/deletion polymorphism Kidney |
| Cough | B2 bradykinin receptor (P30411) | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. [ ADR Type 2 ] | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category