| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
| Capecitabine (154361-50-9) | Diarrhoea | Synergistic | concurrent use of folic acid enhanced capecitabine toxicity | Lethal toxicity of capecitabine due to abusive folic acid prescription?
|
| Capecitabine (154361-50-9) | Hand-And-Foot Syndrome | Synergistic | concurrent use of folic acid enhanced capecitabine toxicity | Lethal toxicity of capecitabine due to abusive folic acid prescription?
|
| Capecitabine (154361-50-9) | Vomiting | Synergistic | concurrent use of folic acid enhanced capecitabine toxicity | Lethal toxicity of capecitabine due to abusive folic acid prescription?
|
| Fluorouracil (51-21-8) | Anorexia | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates
|
| Fluorouracil (51-21-8) | Bloody Diarrhoea | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates
|
| Fluorouracil (51-21-8) | Mouth Ulceration | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates
|
| Fluorouracil (51-21-8) | Vaginal Bleeding | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates
|
| Phenytoin (57-41-0) | Seizure Control Is Partially Or Totally Lost | Antagonistic | Patients taking antiepileptics may have subnormal serum folic acid levels. Frequencies of 27 to 76% have been reported for phenobarbital, primidone, and phenytoin alone or in various ombinations.8 One possible explanation
is that this is due to the enzyme-inducing characteristics of these
antiepileptics, which makes excessive demands on folate for the synthesis
of the enzymes concerned with drug metabolism | Folic acid deficiency in patients receiving anticonvulsant drugs
|