InAADR

Drug Information

Drug Name: Eplerenone (107724-20-9)
PubChem ID: 124040753
SMILES: C[C@]12CCC(=O)C=C1CC(C3[C@]24C(O4)C[C@]5(C3CC[C@]56CCC(=O)O6)C)C(=O)OC
InchiKey: JUKPWJGBANNWMW-GHBUSXCZSA-N
Therapeutic Category: Aldosterone Antagonists, Diuretics, Hormone Antagonists, Hormones, Mineralocorticoid Receptor Antagonists, Natriuretic Agents

Computed Drug Properties

Molecular Weight (dalton): 414.498
LogP: 3.1245
Ring Count: 0
Hydrogen Bond Acceptor Count: 6
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 82.2

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Arrhythmia Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
Grapefruit Juice Hyperkalemia Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Distension MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain MetaADEDB
Abnormal Loss Of Weight MetaADEDB
Accelerated Hypertension MetaADEDB
Aching Muscles MetaADEDB
Acute Hepatic Failure MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Respiratory Failure MetaADEDB
Adrenal Neoplasm MetaADEDB
Afib MetaADEDB
Alanine Aminotransferase Increased ADReCS
Albuminuria ADReCS
Allergic Vasculitis MetaADEDB
Altered State Of Consciousness MetaADEDB
Alveolitis MetaADEDB
Angina MetaADEDB
Angina Pectoris ADReCS
Angiodysplasia MetaADEDB
Angioedema ADReCS
Anhedonia MetaADEDB
Anorexia MetaADEDB
Anticonvulsant Drug Level Increased MetaADEDB
Anxiety MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arterial Stent Insertion MetaADEDB
Arterial Thrombosis Limb MetaADEDB
Arteriosclerosis Coronary Artery MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Asteatosis MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Atelectasis MetaADEDB
Atrial Flutter MetaADEDB
Atrial Tachycardia MetaADEDB
Aura MetaADEDB
Autonomic Neuropathy MetaADEDB
Back Ache MetaADEDB
Bacterial Conjunctivitis MetaADEDB
Basal Cell Carcinoma MetaADEDB
Bile Duct Obstruction MetaADEDB
Bile Duct Stone MetaADEDB
Biliary Fibrosis MetaADEDB
Birth Defect MetaADEDB
Bladder Discomfort MetaADEDB
Bladder Neoplasm MetaADEDB
Bleeding Vaginal SIDER
Bleeding Varicose Vein MetaADEDB
Blood Bilirubin Increased ADReCS
Blood Cholesterol MetaADEDB
Blood Cholesterol Increased ADReCS
Blood Corticotrophin MetaADEDB
Blood Cortisol Decreased MetaADEDB
Blood Cortisol Increased MetaADEDB
Blood Creatine Increased ADReCS
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Creatinine Increased ADReCS
Blood Potassium Increased MetaADEDB
Blood Pressure Inadequately Controlled MetaADEDB
Blood Sodium MetaADEDB
Blood Sodium Decreased ADReCS
Blood Thyroid Stimulating Hormone MetaADEDB
Blood Triglycerides Increased ADReCS
Blood Urea Increased ADReCS
Blood Uric Acid Increased ADReCS
Blood Urine Present MetaADEDB
Body Height Decreased MetaADEDB
Bone Cancer Metastatic MetaADEDB
Brain Concussion MetaADEDB
Brain Death MetaADEDB
Brain Natriuretic Peptide Increased MetaADEDB
Brain Oedema MetaADEDB
Breast Cancer MetaADEDB
Breast Pain ADReCS
Bronchitis MetaADEDB
Bronchopneumonia MetaADEDB
Bundle Branch Block Left MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Disease MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure MetaADEDB
Cardiac Failure Chronic MetaADEDB
Cardiac Fibrillation MetaADEDB
Cardiac Flutter MetaADEDB
Cardiac Murmur MetaADEDB
Cardiac Pseudoaneurysm MetaADEDB
Cardioactive Drug Level Increased MetaADEDB
Cardiogenic Shock MetaADEDB
Cardiomyopathy MetaADEDB
Cardioversion MetaADEDB
Carotidynia MetaADEDB
Catheterisation Cardiac MetaADEDB
Cell Death MetaADEDB
Central Nervous System Inflammation MetaADEDB
Cerebellar Haemangioma MetaADEDB
Cerebellar Haemorrhage MetaADEDB
Cerebral Atrophy MetaADEDB
Cerebral Ischaemia MetaADEDB
Cerumen Impaction MetaADEDB
Chemotherapeutic Drug Level Increased MetaADEDB
Cholangiolitis MetaADEDB
Cholecystitis MetaADEDB
Cholesterol Serum Elevated SIDER
Chronic Kidney Disease MetaADEDB
Claustrophobia MetaADEDB
Clotting MetaADEDB
Coagulation Time Prolonged MetaADEDB
Colitis Ischaemic MetaADEDB
Colon Adenoma MetaADEDB
Colorectal Cancer MetaADEDB
Condition Aggravated MetaADEDB
Congenital Mitral Valve Incompetence MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Constipated MetaADEDB
Continuous Haemodiafiltration MetaADEDB
Coordination Abnormal MetaADEDB
Coronary Angioplasty MetaADEDB
Coronary Artery Occlusion MetaADEDB
Cough ADReCS
Coughing Blood MetaADEDB
Crackles Lung MetaADEDB
Creatinine Increased SIDER
Csf Protein MetaADEDB
Cytolytic Hepatitis MetaADEDB
Decubitus Ulcer MetaADEDB
Dehydration MetaADEDB
Demyelination MetaADEDB
Depersonalisation MetaADEDB
Depressed Mood MetaADEDB
Dermatitides MetaADEDB
Dermatitis ADReCS
Device Dislocation MetaADEDB
Device Failure MetaADEDB
Device Malfunction MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus ADReCS
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diarrhoea ADReCS
Diastolic Dysfunction MetaADEDB
Disorder Peripheral Vascular MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drug Dispensing Error MetaADEDB
Drug Intolerance MetaADEDB
Drug Level Fluctuating MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Drug Withdrawal Maintenance Therapy MetaADEDB
Dysphemia MetaADEDB
Dyspnea Exertional MetaADEDB
Early Morning Awakening MetaADEDB
Eclampsia MetaADEDB
Economic Problem MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electrocardiogram Poor R-Wave Progression MetaADEDB
Electrocardiogram Qrs Complex Abnormal MetaADEDB
Electrocardiogram Qt Prolonged MetaADEDB
Electrocardiogram St-T Change MetaADEDB
Electrocardiogram St-T Segment Abnormal MetaADEDB
Emotional Disorder MetaADEDB
Emotional Distress MetaADEDB
Encephalitis Allergic MetaADEDB
Endometrial Cancer MetaADEDB
Epistaxis MetaADEDB
Erysipelas MetaADEDB
Excess Potassium MetaADEDB
Exposure To Toxic Agent MetaADEDB
Extrasystoles Ventricular MetaADEDB
Eye Rolling MetaADEDB
Face Injury MetaADEDB
Facial Bones Fracture MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue ADReCS
Femur Fracture MetaADEDB
Flank Pain MetaADEDB
Flatulence MetaADEDB
Fluid Overload MetaADEDB
Full Blood Count Decreased MetaADEDB
Gamma-Glutamyltransferase Increased ADReCS
Gangrene MetaADEDB
Gastroenteritis MetaADEDB
Gastroenteritis Viral MetaADEDB
Gastrointestinal Pain ADReCS
General Physical Health Deterioration MetaADEDB
Glucose Intolerance MetaADEDB
Glycosylated Haemoglobin Increased MetaADEDB
Gout MetaADEDB
Gynaecomastia ADReCS
Haemoglobin ADReCS
Haemorrhage ADReCS
Hair Growth Abnormal MetaADEDB
Headache ADReCS
Heart Injury MetaADEDB
Heart Transplant MetaADEDB
Hepatic Atrophy MetaADEDB
Hepatic Congestion MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Failure MetaADEDB
Hepatic Function Abnormal MetaADEDB
Hepatitis Fulminant MetaADEDB
Hepatocellular Injury MetaADEDB
Hepatojugular Reflux MetaADEDB
Hernia Repair MetaADEDB
Histrionic Personality Disorder MetaADEDB
Hyperaldosteronism MetaADEDB
Hypercholesterolaemia ADReCS
Hyperhidrosis MetaADEDB
Hyperkalaemia ADReCS
Hypertriglyceridaemia ADReCS
Hypoaesthesia MetaADEDB
Hypoglycaemia Neonatal MetaADEDB
Hypogonadism MetaADEDB
Hypokalaemia ADReCS
Hyponatraemia ADReCS
Hypophysectomy MetaADEDB
Hypothalamo-Pituitary Disorder MetaADEDB
Hypothyroid MetaADEDB
Hypovolaemia MetaADEDB
Impaired Fasting Glucose MetaADEDB
Implantable Defibrillator Malfunction MetaADEDB
Increased Insulin Requirement MetaADEDB
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Infection Viral MetaADEDB
Infertility MetaADEDB
Influenza ADReCS
Influenza Like Illness ADReCS
International Normalised Ratio Decreased MetaADEDB
Intracardiac Thrombus MetaADEDB
Intraocular Inflammation MetaADEDB
Irregular Menstrual Cycle MetaADEDB
Ischaemic Cardiomyopathy MetaADEDB
Joint Stiffness MetaADEDB
Jugular Vein Distension MetaADEDB
Kidney Failure MetaADEDB
Kidney Function Abnormal ADReCS
Left Atrial Dilatation MetaADEDB
Left Ventricular Dysfunction MetaADEDB
Leg Amputation MetaADEDB
Lividity MetaADEDB
Localised Infection MetaADEDB
Lumbar Spine Flattening MetaADEDB
Lung Edema MetaADEDB
Lung Infection MetaADEDB
Lymphedema MetaADEDB
Macula Lutea Degeneration MetaADEDB
Mediastinitis MetaADEDB
Mental Disorder MetaADEDB
Microalbuminuria ADReCS
Multi-Organ Failure MetaADEDB
Multiple Allergies MetaADEDB
Multiple Injuries MetaADEDB
Muscle Necrosis MetaADEDB
Muscular Dystrophy MetaADEDB
Near Syncope MetaADEDB
Neoplasm Prostate MetaADEDB
Nervous Tension MetaADEDB
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Nightmare MetaADEDB
Occult Blood Positive MetaADEDB
Oedema ADReCS
Oesophageal Varices Haemorrhage MetaADEDB
Oligomenorrhea MetaADEDB
Orthopnea MetaADEDB
Pain ADReCS
Palpitation MetaADEDB
Partner Stress MetaADEDB
Percutaneous Coronary Intervention MetaADEDB
Pericardial Effusion MetaADEDB
Peripheral Embolism MetaADEDB
Peripheral Ischaemia MetaADEDB
Peritoneal Effusion MetaADEDB
Peroneal Nerve Palsy MetaADEDB
Pituitary Haemorrhage MetaADEDB
Platelet Aggregation Inhibition MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pneumonia Fungal MetaADEDB
Pollakiuria MetaADEDB
Polycystic Ovaries MetaADEDB
Polyneuropathy Toxic MetaADEDB
Poor Quality Sleep MetaADEDB
Post Inflammatory Pigmentation Change MetaADEDB
Postoperative Wound Infection MetaADEDB
Postpartum Disorder MetaADEDB
Prostatomegaly MetaADEDB
Protein Urine Absent SIDER
Protein Urine Present ADReCS
Proteinuria ADReCS
Prothrombin Time Prolonged MetaADEDB
Psoriasis MetaADEDB
Pulmonary Hypertension MetaADEDB
Pulmonary Valve Incompetence MetaADEDB
Pyogenic Granuloma MetaADEDB
Rash ADReCS
Renal Artery Stenosis MetaADEDB
Renal Atrophy MetaADEDB
Renal Cancer MetaADEDB
Renal Impairment ADReCS
Respiratory Failure MetaADEDB
Resuscitation MetaADEDB
Right Atrial Dilatation MetaADEDB
Scab MetaADEDB
Scar MetaADEDB
Sclc MetaADEDB
Scleroderma MetaADEDB
Scrotal Swelling MetaADEDB
Sensation Of Heaviness MetaADEDB
Sensory Disturbance MetaADEDB
Serum Creatinine Increased SIDER
Serum Triglycerides Increased SIDER
Sinusitis MetaADEDB
Skin Hypertrophy MetaADEDB
Skin Plaque MetaADEDB
Skin Tightness MetaADEDB
Sleep Apnea MetaADEDB
Small Intestinal Obstruction MetaADEDB
Snoring MetaADEDB
Social Problem MetaADEDB
Sodium Decreased SIDER
Subdural Haemorrhage MetaADEDB
Sudden Cardiac Death MetaADEDB
Supraventricular Tachycardia MetaADEDB
Surgery MetaADEDB
Tachycardia Ventricular MetaADEDB
Thinking Abnormal MetaADEDB
Thyroiditis MetaADEDB
Tonsillectomy MetaADEDB
Trichomoniasis MetaADEDB
Tuberculin Test Positive MetaADEDB
Type 2 Diabetes Mellitus ADReCS
Underdose MetaADEDB
Unemployment MetaADEDB
Unevaluable Event MetaADEDB
Upper Respiratory Tract Inflammation MetaADEDB
Urethral Haemorrhage MetaADEDB
Uterine Cancer MetaADEDB
Vaginal Haemorrhage ADReCS
Vascular Pseudoaneurysm MetaADEDB
Ventricular Fibrillation MetaADEDB
Viral Upper Respiratory Tract Infection MetaADEDB
Vitamin A Deficiency MetaADEDB
Weight Gain MetaADEDB
Wound Infection MetaADEDB
Wound Infection Bacterial MetaADEDB

InAADR: Drug-Protein-ADRs database