| Drug Name: | Enalapril (75847-73-3) |
|---|---|
| PubChem ID: | 5388962 |
| SMILES: | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O |
| InchiKey: | GBXSMTUPTTWBMN-XIRDDKMYSA-N |
| Therapeutic Category: | Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cardiovascular Agents, Enzyme Inhibitors, Protease Inhibitors |
| Molecular Weight (dalton) | : | 376.453 |
| LogP | : | 1.6046 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 95.94 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Allopurinol (315-30-0) | Myocardial Infarction | Antagonistic | Not Understood | Allopurinol and enalapril Drug induced anaphylactic coronary spasm and acute myocardial infarction |
| Orlistat (96829-58-2) | Intracranial Haemorrhage | Antagonistic | Not Understood | Interaction between orlistat and antihypertensive drugs |
| Rifampicin (13292-46-1) | Rise In Blood Pressure | Antagonistic | Not Clear | A possible drug interaction between rifampicin and enalapril |
| Bunazosin (80755-51-7) | Bradycardia | Antagonistic | Selectivity for alpha receptors in the prostate. | Enhancement by an ACE inhibitor of first-dose hypotension caused by an alpha 1-blocker |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Bradycardia | Angiotensin-converting enzyme precursor (P12821) | Renoprotective effects@ blood-pressure reduction@ reduction in left ventricular mass@ endothelial function [ ADR Type 1 ] | Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients-- interaction with ACE insertion/deletion polymorphism Kidney |
| Cough | B2 bradykinin receptor (P30411) | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough. [ ADR Type 2 ] | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough |
| Hepatotoxicity | Cytochrome P450 3A4 (P08684) | Enalapril@ quinapril and fosinopril can also underGO P450 3A-dependent bioactivation and require maintenance of glutathione status for detoxification@ and that captopril causes cytotoxicity independent of cytochrome P450 metabolism |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|---|---|
| Lo salt (a salt substitute containing 34.6 g potassium in every 100 g) | Arrhythmia | Stockley’s drug interactions 8th edition; Stockley’s drug interactions 2008 pocket companion |
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category