InAADR

Drug Information

Drug Name: Diphenhydramine (58-73-1)
PubChem ID: 3100
SMILES: CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
InchiKey: ZZVUWRFHKOJYTH-UHFFFAOYSA-N
Therapeutic Category: Anesthetics, Anti-Allergic Agents, Antiemetics, Autonomic Agents, Central Nervous System Agents, Central Nervous System Depressants, Gastrointestinal Agents, Histamine Agents, Histamine Antagonists, Histamine H1 Antagonists, Hypnotics and Sedatives, Neurotransmitter Agents, Peripheral Nervous System Agents, Sensory System Agents

Computed Drug Properties

Molecular Weight (dalton): 255.361
LogP: 3.3542
Ring Count: 2
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 0
Total Polar Surface Area: 12.47

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Tremor Androgen receptor (P10275) Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Pain MetaADEDB
Abdominal Rigidity MetaADEDB
Abdominal Strangulated Hernia MetaADEDB
Abuse MetaADEDB
Accelerated Hypertension MetaADEDB
Aching Joints MetaADEDB
Acidosis MetaADEDB
Acinetobacter Bacteraemia MetaADEDB
Acquired Epidermolysis Bullosa MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Graft Versus Host Disease In Liver MetaADEDB
Acute Kidney Injury MetaADEDB
Acute Myocardial Infarction MetaADEDB
Acute Pancreatitis MetaADEDB
Acute Respiratory Failure MetaADEDB
Adenomatous Polyposis Coli MetaADEDB
Administration Site Pain MetaADEDB
Adverse Event MetaADEDB
Afib MetaADEDB
Agitated MetaADEDB
Agitation ADReCS
Agoraphobia MetaADEDB
Agranulocytosis ADReCS
Airway Obstruction MetaADEDB
Akathisia Drug-Induced MetaADEDB
Alcohol Consumption MetaADEDB
Allergic Alveolitis MetaADEDB
Allergic Dermatitis MetaADEDB
Alopecia MetaADEDB
Alveolitis MetaADEDB
Amnesia MetaADEDB
Anaemia ADReCS
Anaemia Of Chronic Disease MetaADEDB
Anaesthesia MetaADEDB
Anal Fissure MetaADEDB
Anal Haemorrhage MetaADEDB
Anaphylactic Reaction MetaADEDB
Anaphylactic Shock ADReCS
Androgen Deficiency MetaADEDB
Andropause MetaADEDB
Anemia MetaADEDB
Angiitis MetaADEDB
Angioedema MetaADEDB
Anorexia ADReCS
Anosmia MetaADEDB
Anoxic Encephalopathy MetaADEDB
Anticonvulsant Drug Level Decreased MetaADEDB
Antidepressant Drug Clearance Increased MetaADEDB
Anxiety MetaADEDB
Anxiety Disorders MetaADEDB
Apathy MetaADEDB
Apoplexy MetaADEDB
Appendicitis MetaADEDB
Application Site Vesicles MetaADEDB
Application Site Warmth MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arteriosclerosis MetaADEDB
Arteriosclerosis Coronary Artery MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arteriovenous Fistula Thrombosis MetaADEDB
Aspiration Pneumonia MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Ataxia MetaADEDB
Atelectasis MetaADEDB
Athetosis MetaADEDB
Atrial Tachycardia MetaADEDB
Atrophy MetaADEDB
Back Ache MetaADEDB
Bacterial Culture Positive MetaADEDB
Bacterial Toxaemia MetaADEDB
Balance Disorder MetaADEDB
Basal Ganglia Diseases MetaADEDB
Basedow Disease MetaADEDB
Belligerence MetaADEDB
Benign Lung Neoplasm MetaADEDB
Biliary Dilatation MetaADEDB
Bipolar Disorder MetaADEDB
Bleb MetaADEDB
Bleeding Vaginal MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Culture Positive MetaADEDB
Blood Glucose Decreased MetaADEDB
Blood Osmolarity Increased MetaADEDB
Blood Phosphorus Increased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Pressure Diastolic Decreased MetaADEDB
Blood Pressure Systolic Increased MetaADEDB
Blood Testosterone Decreased MetaADEDB
Blood Thyroid Stimulating Hormone MetaADEDB
Blood Thyroid Stimulating Hormone Increased MetaADEDB
Blunted Affect MetaADEDB
Blurred Vision MetaADEDB
Body Temperature Increased MetaADEDB
Bradycardia MetaADEDB
Bradypnoea MetaADEDB
Brain Damage MetaADEDB
Brain Oedema MetaADEDB
Brain Stem Infarction MetaADEDB
Breast Cancer Stage Iii MetaADEDB
Breast Cellulitis MetaADEDB
Breast Discharge MetaADEDB
Breast Injury MetaADEDB
Bronchial Hyperactivity MetaADEDB
Bronchitis MetaADEDB
Bronchitis MetaADEDB
Bruise MetaADEDB
Bruxism MetaADEDB
Bundle Branch Block Right MetaADEDB
Burn Oesophageal MetaADEDB
Burning Sensation Mucosal MetaADEDB
Bursitis MetaADEDB
Caecitis MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Enzymes Increased MetaADEDB
Cardiac Valve Disease MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardiomyopathy MetaADEDB
Carotid Artery Stenosis MetaADEDB
Catalepsy MetaADEDB
Cataract MetaADEDB
Catatonia MetaADEDB
Catheter Site Haemorrhage MetaADEDB
Catheter Site Infection MetaADEDB
Cellulitis MetaADEDB
Cerebellar Artery Thrombosis MetaADEDB
Cerebral Infarct MetaADEDB
Chest Discomfort ADReCS
Chest Pain ADReCS
Chest Tightness ADReCS
Chill MetaADEDB
Chills ADReCS
Choking Sensation MetaADEDB
Cholecystitis Chronic MetaADEDB
Chronic Kidney Disease MetaADEDB
Chronic Obstructive Airway Disease MetaADEDB
Chronic Respiratory Failure MetaADEDB
Chronic Sinusitis MetaADEDB
Cirrhosis MetaADEDB
Clostridium Difficile Colitis MetaADEDB
Cognition Disorders MetaADEDB
Colitis MetaADEDB
Colon Adenoma MetaADEDB
Colon Spastic MetaADEDB
Coma MetaADEDB
Common Cold MetaADEDB
Compulsive Shopping MetaADEDB
Conduct Disorder MetaADEDB
Confusion MetaADEDB
Confusional State ADReCS
Congestive Cardiomyopathy MetaADEDB
Conjunctival Deposit MetaADEDB
Consciousness Disorders MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Contact Dermatitis MetaADEDB
Convulsion ADReCS
Coordination Abnormal ADReCS
Cough MetaADEDB
Cramp MetaADEDB
Crohn Disease MetaADEDB
Culture Positive MetaADEDB
Culture Stool Positive MetaADEDB
Cyanosis MetaADEDB
Cytomegalovirus Oesophagitis MetaADEDB
Dandruff MetaADEDB
Decreased Appetite ADReCS
Decubitus Ulcer MetaADEDB
Deep Vein Thromboses MetaADEDB
Deglutition Disorders MetaADEDB
Dehydration MetaADEDB
Delirium MetaADEDB
Dependence MetaADEDB
Depressive Symptom MetaADEDB
Dermatitides MetaADEDB
Dermatitis ADReCS
Dermatosis MetaADEDB
Dermographism MetaADEDB
Device Related Infection MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus Inadequate Control MetaADEDB
Diabetes Mellitus Insulin-Dependent MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Complication MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diplopia ADReCS
Disorders Of Excessive Somnolence MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Disseminated Tuberculosis MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drowsiness SIDER
Drug Administration Error MetaADEDB
Drug Eruption ADReCS
Drug Eruptions MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Intolerance MetaADEDB
Drug Level Fluctuating MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Eye MetaADEDB
Dry Mouth ADReCS
Dry Throat ADReCS
Dysarthria MetaADEDB
Dyskinesia Drug-Induced MetaADEDB
Dyskinesias MetaADEDB
Dyspepsia ADReCS
Dysthymic Disorder MetaADEDB
Dystonia MetaADEDB
Dystonic Disorders MetaADEDB
Dysuria ADReCS
Ear Disorder MetaADEDB
Early Morning Awakening MetaADEDB
Eczema Infected MetaADEDB
Edema MetaADEDB
Edema Extremities MetaADEDB
Electromechanical Dissociation MetaADEDB
Embolism Pulmonary MetaADEDB
Emotional Distress MetaADEDB
Encephalitis Allergic MetaADEDB
Encephalopathy MetaADEDB
Endocardial Fibrosis MetaADEDB
Endometrial Cancer Stage I MetaADEDB
Endometrial Cancer Stage Ii MetaADEDB
Endometrial Neoplasms MetaADEDB
Engraftment Syndrome MetaADEDB
Epigastric Discomfort ADReCS
Epigastric Distress SIDER
Eruption MetaADEDB
Erythema Migrans MetaADEDB
Erythema Multiforme MetaADEDB
Euphoric Mood ADReCS
Exanthema MetaADEDB
Excess Potassium MetaADEDB
Extrasystoles ADReCS
Extremity Pain MetaADEDB
Eye Rolling MetaADEDB
Eye Swelling MetaADEDB
Facial Flushing MetaADEDB
Facial Nerve Diseases MetaADEDB
Failure To Thrive MetaADEDB
Fatigue ADReCS
Febrile Neutropenia MetaADEDB
Feeling Abnormal ADReCS
Feeling Cold MetaADEDB
Fetal Diseases MetaADEDB
Fever MetaADEDB
Fib MetaADEDB
Flank Pain MetaADEDB
Flooding MetaADEDB
Flu MetaADEDB
Fluid Overload MetaADEDB
Fractured Coccyx MetaADEDB
Fungal Disease MetaADEDB
Fungal Sepsis MetaADEDB
Gait Disorders Neurologic MetaADEDB
Gallbladder Enlargement MetaADEDB
Gambling MetaADEDB
Gangrene MetaADEDB
Gastric Hypermotility MetaADEDB
Gastric Hyperplasia MetaADEDB
Gastric Ulcer MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Disorder MetaADEDB
Glioblastoma Multiforme MetaADEDB
Granulocytosis MetaADEDB
Haematoma Evacuation MetaADEDB
Haemolytic Anaemia ADReCS
Haemorrhagic Anaemia MetaADEDB
Haemorrhoids MetaADEDB
Hallucinations MetaADEDB
Headache ADReCS
Heart Attack MetaADEDB
Heart Failure MetaADEDB
Heart Rate Increased MetaADEDB
Heat Stroke MetaADEDB
Hemiparesis MetaADEDB
Heparin-Induced Thrombocytopenia MetaADEDB
Hepatic Failure MetaADEDB
Hepatic Fibrosis MetaADEDB
Hepatic Vein Occlusion MetaADEDB
Hepatitis A MetaADEDB
Hepatitis B MetaADEDB
Hepatitis C MetaADEDB
Hepatosplenomegaly MetaADEDB
Herpes Zoster MetaADEDB
Hiccough MetaADEDB
Hyperalgesia MetaADEDB
Hyperalimentation MetaADEDB
Hyperglycemia MetaADEDB
Hyperhidrosis ADReCS
Hyperkinesis MetaADEDB
Hypersensitivity MetaADEDB
Hypersexuality MetaADEDB
Hypertonic Bladder MetaADEDB
Hypesthesia MetaADEDB
Hypoglycemia MetaADEDB
Hypokalaemia MetaADEDB
Hypokalemia MetaADEDB
Hypomagnesaemia MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Hypothyroid MetaADEDB
Hypovolaemia MetaADEDB
Hysterectomy MetaADEDB
Ileitis MetaADEDB
Immunosuppression MetaADEDB
Impaired Driving Ability MetaADEDB
Impaired Gastric Emptying MetaADEDB
Implant Site Reaction MetaADEDB
Impulsive Behaviour MetaADEDB
Incoherent MetaADEDB
Incontinence MetaADEDB
Incorrect Dose Administered MetaADEDB
Increased Bronchial Secretion ADReCS
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Infection Viral MetaADEDB
Inflammatory Bowel Disease MetaADEDB
Influenza Like Illness MetaADEDB
Infusion Related Reaction MetaADEDB
Injection Site Coldness MetaADEDB
Injection Site Erythema MetaADEDB
Injection Site Pruritus MetaADEDB
Injection Site Urticaria MetaADEDB
Insomnia ADReCS
Intentional Drug Misuse MetaADEDB
International Normalised Ratio Decreased MetaADEDB
Intestinal Functional Disorder MetaADEDB
Irritability ADReCS
Ischaemic Hepatitis MetaADEDB
Itch MetaADEDB
Kidney Failure MetaADEDB
Klebsiella Sepsis MetaADEDB
Labyrinthitis ADReCS
Laryngeal Diseases MetaADEDB
Laryngismus MetaADEDB
Left Atrial Dilatation MetaADEDB
Lethargy MetaADEDB
Leucopenia MetaADEDB
Leukopenia MetaADEDB
Leukopenia Neonatal MetaADEDB
Ligament Sprain MetaADEDB
Lip Blister MetaADEDB
Lip Disorder MetaADEDB
Listeria Sepsis MetaADEDB
Liver Failure Acute MetaADEDB
Long Qt Syndrome MetaADEDB
Lung Adenocarcinoma MetaADEDB
Lung Edema MetaADEDB
Lung Infection MetaADEDB
Lung Infiltration MetaADEDB
Lung Injury MetaADEDB
Major Depression MetaADEDB
Malignant Hypertension MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Malnourished MetaADEDB
Melanocytic Naevus MetaADEDB
Melanoma MetaADEDB
Meningioma MetaADEDB
Meningitides MetaADEDB
Meniscus Lesion MetaADEDB
Menstrual Disorder MetaADEDB
Menstruation Irregular ADReCS
Mental Status Changes MetaADEDB
Metabolic Encephalopathy MetaADEDB
Metaplasia MetaADEDB
Metastases To Lung MetaADEDB
Micturition Disorder ADReCS
Migraine Disorders MetaADEDB
Mood Disorder Due To A General Medical Condition MetaADEDB
Mood Disorders MetaADEDB
Motor Skills Disorders MetaADEDB
Mouth Bleeding MetaADEDB
Movement Disorders MetaADEDB
Mucosal Inflammation MetaADEDB
Multi-Organ Disorder MetaADEDB
Multi-Organ Failure MetaADEDB
Multiple Sclerosis MetaADEDB
Muscle Inflammation MetaADEDB
Muscle Injury MetaADEDB
Muscle Rigidity MetaADEDB
Muscle Tightness MetaADEDB
Nasal Congestion ADReCS
Nasal Dryness ADReCS
Nasal Sinus Congestion MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Necrosis MetaADEDB
Nephrogenic Fibrosing Dermopathy MetaADEDB
Nervous Tension MetaADEDB
Nervousness ADReCS
Neumonia MetaADEDB
Neuritis ADReCS
Neurobehavioral Manifestations MetaADEDB
Neuroleptic Malignant Syndrome MetaADEDB
Neuropathy Peripheral ADReCS
Neutropenia MetaADEDB
Neutropenic Sepsis MetaADEDB
Neutrophil Count Decreased MetaADEDB
Nicotine Dependence MetaADEDB
Night Blindness MetaADEDB
No Reaction On Previous Exposure To Drug MetaADEDB
Nodule MetaADEDB
Ocular Motility Disorders MetaADEDB
Oliguria MetaADEDB
Onychomadesis MetaADEDB
Open Reduction Of Fracture MetaADEDB
Oropharyngeal Pain MetaADEDB
Orthopnea MetaADEDB
Overdose MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain MetaADEDB
Pallor MetaADEDB
Palpitations ADReCS
Pancreatic Pseudocyst MetaADEDB
Pancreatitis MetaADEDB
Pancreatitis Chronic MetaADEDB
Paraesthesia ADReCS
Paranoid Disorders MetaADEDB
Parkinson Disease Secondary MetaADEDB
Pedal Pulse Absent MetaADEDB
Pericardial Effusion MetaADEDB
Peripheral Nervous System Diseases MetaADEDB
Peripheral Occlusive Disease MetaADEDB
Perirectal Abscess MetaADEDB
Peritonitis Bacterial MetaADEDB
Peritonsillitis MetaADEDB
Pharyngeal Inflammation MetaADEDB
Pharyngolaryngeal Pain MetaADEDB
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Pigmentation Disorder MetaADEDB
Poisoning MetaADEDB
Pollakiuria ADReCS
Polyuria MetaADEDB
Poor Sucking Reflex MetaADEDB
Poor Venous Access MetaADEDB
Post Procedural Haemorrhage MetaADEDB
Post Procedural Infection MetaADEDB
Postictal State MetaADEDB
Prinzmetal Angina MetaADEDB
Proctalgia MetaADEDB
Pruritus MetaADEDB
Pruritus Generalised MetaADEDB
Psychomotor Agitation MetaADEDB
Psychomotor Disorders MetaADEDB
Psychoses Substance-Induced MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Hypertension MetaADEDB
Rash ADReCS
Rash Generalised MetaADEDB
Reaction To Colouring MetaADEDB
Renal Cyst MetaADEDB
Renal Tubular Necrosis MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Rate Increased MetaADEDB
Respiratory Syncytial Virus Infection MetaADEDB
Restlessness ADReCS
Rhabdomyolysis MetaADEDB
Rhonchi MetaADEDB
Road Traffic Accident MetaADEDB
Scar MetaADEDB
Screaming MetaADEDB
Sedation ADReCS
Seizures MetaADEDB
Self Injurious Behaviour MetaADEDB
Semen Volume Decreased MetaADEDB
Sepsis Syndrome MetaADEDB
Serum Sickness MetaADEDB
Shock ADReCS
Shock Septic MetaADEDB
Shoulder Operation MetaADEDB
Sinusitis MetaADEDB
Skeletal Injury MetaADEDB
Skin Desquamation MetaADEDB
Skin Discolouration MetaADEDB
Sleep Initiation And Maintenance Disorders MetaADEDB
Sleep Phase Rhythm Disturbance MetaADEDB
Sleep Talking MetaADEDB
Soft Tissue Injuries MetaADEDB
Somnambulism MetaADEDB
Somnolence ADReCS
Spasm MetaADEDB
Speech Disorder MetaADEDB
Speech Disorders MetaADEDB
Spinning Sensation MetaADEDB
Splenic Infarction MetaADEDB
Stevens-Johnson Syndrome MetaADEDB
Still Disease Adult Onset MetaADEDB
Stress MetaADEDB
Subcutaneous Emphysema MetaADEDB
Substance Abuse MetaADEDB
Substance Withdrawal Syndrome MetaADEDB
Sudden Death MetaADEDB
Sweating SIDER
Sweating Increased SIDER
Swollen Tongue MetaADEDB
Tachycardia ADReCS
Tachycardia Sinus MetaADEDB
Tachycardia Ventricular MetaADEDB
Tendon Injury MetaADEDB
Tension ADReCS
Therapeutic Response Unexpected MetaADEDB
Therapy Non-Responder MetaADEDB
Throat Tightness ADReCS
Thrombocytopenia ADReCS
Thyroid Mass MetaADEDB
Tinea MetaADEDB
Tinnitus ADReCS
Tobacco User MetaADEDB
Tonsillitis MetaADEDB
Tooth Discolouration MetaADEDB
Tooth Disease MetaADEDB
Torticollis MetaADEDB
Tracheal Stenosis MetaADEDB
Transient Ischaemic Attack MetaADEDB
Tremor ADReCS
Trichomoniasis MetaADEDB
Trismus MetaADEDB
Tumour Lysis Syndrome MetaADEDB
Ultrasound Pelvis MetaADEDB
Unresponsive To Stimuli MetaADEDB
Upper Gastrointestinal Bleeding MetaADEDB
Urinary Retention ADReCS
Urinary Tract Infection Fungal MetaADEDB
Urinary Tract Obstruction ADReCS
Urticaria ADReCS
Vascular Cauterisation MetaADEDB
Vasculitis Leukocytoclastic Cutaneous MetaADEDB
Venoocclusive Disease MetaADEDB
Ventricular Fibrillation MetaADEDB
Vertigo ADReCS
Vision Blurred ADReCS
Voice Disorders MetaADEDB
Vomiting ADReCS
Water Pollution MetaADEDB
Wheezing ADReCS
Xerosis MetaADEDB
Xerostomia MetaADEDB

InAADR: Drug-Protein-ADRs database