| Drug Name: | Dicloxacillin (3116-76-5) |
|---|---|
| PubChem ID: | 18381 |
| SMILES: | CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O |
| InchiKey: | YFAGHNZHGGCZAX-JKIFEVAISA-N |
| Therapeutic Category: | Anti-Bacterial Agents, Anti-Infective Agents |
| Molecular Weight (dalton) | : | 470.334 |
| LogP | : | 3.20212 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 112.74 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Infusion Phlebitis | Intercellular adhesion molecule 1 precursor (P05362) | Despite constitutive expression of ICAM-1 (34%) in HUVEC@ dicloxacillin or erythromycin significantly increased the number of cells with ICAM-1 expression by 37% and 30%@ respectively@which leads to pathogenesis of infusion phlebitis [ ADR Type 1 ] | Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category