| Drug Name: | Dapsone (80-08-0) |
|---|---|
| PubChem ID: | 2955 |
| SMILES: | C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N |
| InchiKey: | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-Bacterial Agents, Anti-Infective Agents, Antimalarials, Antiparasitic Agents, Antiprotozoal Agents, Enzyme Inhibitors, Folic Acid Antagonists, Leprostatic Agents |
| Molecular Weight (dalton) | : | 248.307 |
| LogP | : | 1.6838 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 86.18 |
This panel provides information on interacting drugs and their ADRs along with references
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Agranulocytosis | Myeloperoxidase precursor (P05164) | N-chlorosulfamethoxazole product was formed when dapsone was N-chlorinated by the MPO system@which is responsible for agranulocytosis. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Hypersensitivity | N-acetyltransferase (P61599) | Hypersensitivity [ ADR Type 5 ] | Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW |
| Lupus | Myeloperoxidase precursor (P05164) | N-chlorosulfamethoxazole product was formed when dapsone was N-chlorinated by the MPO system@which is responsible for drug-induced lupus [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|---|---|---|---|
| hydroxylamine metabolite | Hemotoxicity | Managing the challenge of chemically reactive metabolites in drug development | ||
| N-hydroxydapsone | Methaemoglobin Formation | Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites |
This panel provides information on drug category