| Drug Name: | Cocaine (50-36-2) |
|---|---|
| PubChem ID: | 446220 |
| SMILES: | CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC |
| InchiKey: | ZPUCINDJVBIVPJ-LJISPDSOSA-N |
| Therapeutic Category: | Anesthetics, Cardiovascular Agents, Central Nervous System Agents, Central Nervous System Depressants, Dopamine Agents, Dopamine Uptake Inhibitors, Membrane Transport Modulators, Neurotransmitter Agents, Neurotransmitter Uptake Inhibitors, Peripheral Nervous System Agents, Sensory System Agents, Vasoconstrictor Agents |
| Molecular Weight (dalton) | : | 303.358 |
| LogP | : | 1.8677 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 55.84 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Amphetamine (300-62-9) | Ischaemic Stroke | Additive | Not Clear | Amphetamine poisoning: effectiveness of chlorpromazine |
| Propofol (2078-54-8) | Convulsions | Antagonistic | Not Understood | Convulsions after cocaine and propofol |
| Indomethacin (53-86-1) | Haematemesis | Additive | Both drugs can cause gastrointestinal bleeding, which would account for the haematemesis | Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding |
| Methadone (76-99-3) | Torsade De Pointes | Additive | Not Known | Cocaine-related torsade de pointes in a methadone maintenance patient |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Hepatic Injury | Alanine aminotransferase (P24298) | In the case of cocaine@ adrenergic antaGOnist cotreatment was capable of reducing serum alanine aminotransferase activities by approximately 50%@creating the potential for increased susceptibility to hepatic injury [ ADR Type 1 ] | Adrenergic modulation of hepatotoxicity |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category