| Drug Name: | Chlorpromazine (50-53-3) |
|---|---|
| PubChem ID: | 2726 |
| SMILES: | CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl |
| InchiKey: | ZPEIMTDSQAKGNT-UHFFFAOYSA-N |
| Therapeutic Category: | Antiemetics, Antipsychotic Agents, Autonomic Agents, Central Nervous System Agents, Central Nervous System Depressants, Dopamine Agents, Dopamine Antagonists, Gastrointestinal Agents, Neurotransmitter Agents, Peripheral Nervous System Agents, Psychotropic Drugs, Tranquilizing Agents |
| Molecular Weight (dalton) | : | 318.873 |
| LogP | : | 4.8944 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 6.48 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Piperazine (110-85-0) | Convulsions | Antagonistic | Not fully understood | Reaction between paperazine and chlorpromazine |
| Amphetamine (300-62-9) | Antagonises The Apetite Supressant Effect Of Amfetamines | Antagonistic | Not Understood | Asystole and bradycardia during dipyridamole stress testing in patients receiving beta blockers |
| Thalidomide (50-35-1) | Cns Depression | Additive | Thalidomide increases the effect of other CNS depressants, | Clinical pharmacokinetics of thalidomide |
| Benzatropine (86-13-5) | Adynamic Ileus | Additive | Antimuscarinic (anticholinergic) drugs inhibit the parasympathetic nervous system, which innervates the sweat glands, so that when the ambient temperature rises the major body heat-losing mechanism can be partially or wholly lost | Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drugtherapy |
| Benzatropine (86-13-5) | Constipation | Additive | Antimuscarinic (anticholinergic) drugs inhibit the parasympathetic nervous system, which innervates the sweat glands, so that when the ambient temperature rises the major body heat-losing mechanism can be partially or wholly lost | Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drugtherapy |
| Benzatropine (86-13-5) | Heat Stroke | Additive | Antimuscarinic (anticholinergic) drugs inhibit the parasympathetic nervous system, which innervates the sweat glands, so that when the ambient temperature rises the major body heat-losing mechanism can be partially or wholly lost | Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drugtherapy |
| Lithium (7439-93-2) | Neurotoxicity | Antagonistic | Not understood | Effect of lithium on plasma chlorpromazine levels |
| Pethidine (57-42-1) | Respiratory Depression | Additive | Chlorpromazine can increase the activity of the liver microsomal enzymes so that the metabolism of pethidine to norpethidine and norpethidinic acid are increased which are toxic metabolites of pethidine | Drug interaction: meperidine and chlorpromazine, a toxic combination |
| Captopril (62571-86-2) | Bradycardia | Antagonistic | Uncertain | Hypotension with postural syncope secondary to the combination of chlorpromazine and captopril |
| Valproic Acid (99-66-1) | Hepatotoxicity | Synergistic | reduction in liver metabolism | The effects of neuroleptics (haloperidol and chlorpromazine) on the pharmacokinetics of valproic acid in schizophrenic patients |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Akathisia | D(2) dopamine receptor (P14416) | Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] | Pharmacogenetics and antipsychotic drugs |
| Akathisia | D(3) dopamine receptor (P35462) | Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] | Pharmacogenetics and antipsychotic drugs |
| Akathisia | D(4) dopamine receptor (P21917) | Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] | Pharmacogenetics and antipsychotic drugs |
| Hepatotoxicity | Glutamate pyruvate transaminase (Q28DB5) | A toxic dose of the drug (LD20)produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration@which leads to hepatotoxicity of acetaminophen in neonatal and young rats [ ADR Type 1 ] | Hepatotoxicity of acetaminophen in neonatal and young rats I Age-related changes in susceptibility |
| Hepatotoxicity | L-lactate dehydrogenase (P00338) | A toxic dose of the drug (LD20)produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration,which leads to hepatotoxicity of acetaminophen in neonatal and young rats. [ ADR Type 1 ] | Hepatotoxicity of acetaminophen in neonatal and young rats I Age-related changes in susceptibility |
| Parkinsonism | NADH-ubiquinone oxidoreductase chain 1 (P03886) | Chlorpromazine produces parkinsonism apparently through inhibition of NADH:ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain. [ ADR Type 1 ] | Neuroleptic medications inhibit complex I of the electron transport chain |
| Rotational Behavior | Cholinergic receptor muscarinic (Q53XZ3) | Nuclear groups adjacent to the IVth ventricle@ which are rich in muscarinic cholinergic receptors@ include locus coeruleus and vestibular nuclear complex (VNC)@their injections were significantly more likely to induce rotation [ ADR Type 1 ] | Chlorpromazine methiodide acts at the vestibular nuclear complex to induce barrel rotation in the rat |
| Rotational Behavior | Vestibular nuclear complex (VNC) (P00063) | Nuclear groups adjacent to the IVth ventricle, which are rich in muscarinic cholinergic receptors, include locus coeruleus and vestibular nuclear complex (VNC),their injections were significantly more likely to induce rotation. [ ADR Type 1 ] | Chlorpromazine methiodide acts at the vestibular nuclear complex to induce barrel rotation in the rat |
| Stimulated Ornithine Decarboxylase Activity | Ornithine decarboxylase (P11926) | Single dose of chlorpromazine stimulated ornithine decarboxylase activity 7-fold and decreased S-adenosylmethionine decarboxylase activity to 50% from the control level [ ADR Type 1 ] | The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine Dependence of ornithine decarboxylase induction |
| Stimulated Ornithine Decarboxylase Activity | S-adenosylmethionine decarboxylase (P17707) | Single dose of chlorpromazine stimulated ornithine decarboxylase activity 7-fold and decreased S-adenosylmethionine decarboxylase activity to 50% from the control level [ ADR Type 1 ] | The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine Dependence of ornithine decarboxylase induction |
| Tardive Dyskinesia | D(2) dopamine receptor (P14416) | Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] | Pharmacogenetics and antipsychotic drugs |
| Tardive Dyskinesia | D(3) dopamine receptor (P35462) | Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3) [ ADR Type 2 ] | Pharmacogenetics and antipsychotic drugs |
| Tardive Dyskinesia | D(4) dopamine receptor (P21917) | Antipsychotic response (D2@ D3@ D4)@antipsychotic-induced tardive dyskinesia (D3)@antipsychotic-induced acute akathisia (D3). [ ADR Type 2 ] | Pharmacogenetics and antipsychotic drugs |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category