| Drug Name: | Carbachol (51-83-2) |
|---|---|
| PubChem ID: | 5831 |
| SMILES: | C[N+](C)(C)CCOC(=O)N.[Cl-] |
| InchiKey: | AIXAANGOTKPUOY-UHFFFAOYSA-N |
| Therapeutic Category: | Analgesics, Autonomic Agents, Cardiotonic Agents, Cardiovascular Agents, Central Nervous System Agents, Cholinergic Agents, Cholinergic Agonists, Miotics, Neurotransmitter Agents, Peripheral Nervous System Agents, Protective Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 182.651 |
| LogP | : | -3.2081 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 52.32 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Acth | Cytochrome c oxidase (P00395) | The involvement of prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH. [ ADR Type 1 ] | Effect of constitutive- and inducible-cyclooxygenase in the carbachol-induced pituitary-adrenocortical response during social stress |
| Acth | Prostaglandin E2 receptor (Q9BGL8) | The involvement of prostaglandins (PGs) generated by constitutive and inducible cyclooxygenase (COX-1 and COX-2) in the carbachol-induced ACTH [ ADR Type 1 ] | Effect of constitutive- and inducible-cyclooxygenase in the carbachol-induced pituitary-adrenocortical response during social stress |
| Bradycardia | Muscarinic acetylcholine receptor M2 (P08172) | Carbamylcholine produced bradycardia through the low-affinity state of the M(2) receptor [ ADR Type 1 ] | Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor aGOnists sabcomeline and xanomeline |
| Caudal-Rostral Seizure Generalization | Proto-oncogene protein c-fos (P01100) | Rats with seizures induced by PAG carbachol microinjections exhibited dense c-fos-like immunoreactivity in the dentate gyrus,which is proposed that the PAG serves as a pathway for caudal-rostral seizure generalization [ ADR Type 1 ] | Focal microinjection of carbachol into the periaqueductal gray induces seizures in the forebrain of the rat |
| Hyperglycaemia | immunoreactive GlucaGOn (P29794) | The injection of adrenaline and carbachol into the third cerebral ventricle resulted in a marked hyperglycaemia associated with increased immunoreactive glucaGOn [ ADR Type 5 ] | Central hyperglycaemic effect of adrenaline and carbachol |
| Steroidogenic Refractoriness | Muscarinic acetylcholine receptor M3 (P20309) | Carbachol stimulates cortisol production in bovine ZFR cells via muscarinic receptor M(3)@which suggests that carbachol induces homologous steroidogenic refractoriness of ZFR cells. [ ADR Type 1 ] | Carbachol induces homologous steroidogenic refractoriness of bovine fasciculata-reticularis cells |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category