| Drug Name: | urokinase-type Plasminogen activator (pro-u-PA) (CASNA00114) |
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This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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| Cell Cytoskeleton Reorganization | Integrin alpha-V (P06756) | Induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
| Cell Cytoskeleton Reorganization | Urokinase plasminogen activator surface receptor (Q03405) | induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration. [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
| Cell Migration | Integrin alpha-V (P06756) | Induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
| Cell Migration | SRC tyrosine kinase (P41240) | Induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration. [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category
| Toxicity | Source |
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