This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Cell Lysis | Adenosine deaminase (P00813) | The DNA cleavage and subsequent cell lysis might be related to the selective thymocyte deletion observed in patients with adenosine deaminase deficiency [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes
|
| Cell Lysis | L-lactate dehydrogenase (P00338) | The inhibition of DNA cleavage was accompanied by a reduction in lactate dehydrogenase release, suggesting a causal relationship between DNA cleavage and cell death [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes
|
| Thymocyte Deletion | L-lactate dehydrogenase (P00338) | The inhibition of DNA cleavage was accompanied by a reduction in lactate dehydrogenase release, suggesting a causal relationship between DNA cleavage and cell death [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes
|
| Thymocyte Deletion | Purine nucleoside phosphorylase (P00491) | The DNA cleavage and subsequent cell lysis might be related to the selective thymocyte deletion observed in patients with purine nucleoside phosphorylase deficiency [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes
|
This panel provides drug-food interactions and their ADRs along with references
This panel provides information on drug category