| Drug Name: | Bromocriptine (25614-03-3) |
|---|---|
| PubChem ID: | 31101 |
| SMILES: | CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O |
| InchiKey: | OZVBMTJYIDMWIL-AYFBDAFISA-N |
| Therapeutic Category: | Anti-Dyskinesia Agents, Antiparkinson Agents, Central Nervous System Agents, Dopamine Agents, Dopamine Agonists, Hormone Antagonists, Hormones, Neurotransmitter Agents |
| Molecular Weight (dalton) | : | 654.606 |
| LogP | : | 3.1928 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 118.21 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Erythromycin (114-07-8) | Psychotic Behavior | Synergistic | Bromocriptine metabolise by the cytochrome P450 isoenzyme CYP3A4. Erythromycin inhibit this metabolism | Pharmacokinetic evaluation of erythromycin and caffeine administered with bromocriptine |
| Griseofulvin (126-07-8) | Reduce The Efficacy Of Bromocriptine | Antagonistic | Unknown | Metabolic and clinical studies on patients with acromegaly treated with bromocriptine over 22 months |
| Metoclopramide (364-62-5) | Reduce The Efficacy Of Dopamine Agonists | Antagonistic | Metoclopramide crosses the blood brain barrier and has central dopamine antagonist effects | Vancomycin Ototoxicity and Nephrotoxicity |
| Phenylpropanolamine (14838-15-4) | Vasospasm Cerebral | Additive | Not understood | Bromocriptine-associated headache: possible life-threatening sympathomimetic interaction |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category