This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug |
Toxicity |
Interaction Type |
Mechanism |
Reference |
|---|
| Trihexyphenidyl (144-11-6) | Blurred Vision | Additive | Additive antimuscarinic effects, both peripheral and central | Anticholinergic side effects of trazodone combined with another pharmacologic agent
|
| Trihexyphenidyl (144-11-6) | Constipation | Additive | Additive antimuscarinic effects, both peripheral and central | Anticholinergic side effects of trazodone combined with another pharmacologic agent
|
| Trihexyphenidyl (144-11-6) | Dry Mouth | Additive | Additive antimuscarinic effects, both peripheral and central | Anticholinergic side effects of trazodone combined with another pharmacologic agent
|
| Trihexyphenidyl (144-11-6) | Tachycardia | Additive | Additive antimuscarinic effects, both peripheral and central | Anticholinergic side effects of trazodone combined with another pharmacologic agent
|
| Trihexyphenidyl (144-11-6) | Urination Difficulty | Additive | Additive antimuscarinic effects, both peripheral and central | Anticholinergic side effects of trazodone combined with another pharmacologic agent
|
| Chlorpromazine (50-53-3) | Adynamic Ileus | Additive | Antimuscarinic (anticholinergic) drugs inhibit the parasympathetic nervous system, which innervates the sweat glands, so that when the ambient temperature rises the major body heat-losing mechanism can be partially or wholly lost | Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drugtherapy
|
| Chlorpromazine (50-53-3) | Constipation | Additive | Antimuscarinic (anticholinergic) drugs inhibit the parasympathetic nervous system, which innervates the sweat glands, so that when the ambient temperature rises the major body heat-losing mechanism can be partially or wholly lost | Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drugtherapy
|
| Chlorpromazine (50-53-3) | Heat Stroke | Additive | Antimuscarinic (anticholinergic) drugs inhibit the parasympathetic nervous system, which innervates the sweat glands, so that when the ambient temperature rises the major body heat-losing mechanism can be partially or wholly lost | Heat dyscontrol syndrome in patients receiving antipsychotic, antidepressant and antiparkinson drugtherapy
|
| Fluoxetine (54910-89-3) | Delirium | Additive | additive antimuscarinic interactions | Delirium associated with the combination of a neuroleptic, an SSRI, and benztropine
|