This panel provides drug-protein interaction and their ADRs along with references
| Toxicity |
Interacting Protein |
Mechanism |
Reference |
| Anemia | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Anemia | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Anemia | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Apoptosis | BAX protein (Q07815) | Arsenic trioxide-induced death of neuroblastoma cells involves activation of BAX and does not require p53@SO activation of Bax is an important event in As(2)O(3)-induced cell death. [ ADR Type 2 ] | Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53
|
| Cardiovascular Disease | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Cardiovascular Disease | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Cardiovascular Disease | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Cytotoxicity | Caspase-3 (P42574) | As(2)O(3) also caused an INCREASE of cytoplasmic cytochrome c@ translocation of antiapoptosis-inducing factor to the nuclei@ and a slight ACTIVATION of caspase 3@suggesting activation of a cytotoxic pathway different from that induced by conventional chemotherapeutic agents. [ ADR Type 2 ] | Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53
|
| Developmental Abnormalities | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Developmental Abnormalities | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Developmental Abnormalities | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Diabetes | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Diabetes | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Diabetes | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Eosinophilia | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Eosinophilia | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Eosinophilia | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Fibrosis Of Kidney | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Fibrosis Of Kidney | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Fibrosis Of Kidney | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Fibrosis Of Liver | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Fibrosis Of Liver | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Fibrosis Of Liver | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Hearing Loss | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Hearing Loss | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Hearing Loss | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Leukopenia | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Leukopenia | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Leukopenia | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Neurologic And Neurobehavioral Disorder | HMTIIA (P00023) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Neurologic And Neurobehavioral Disorder | Proto-oncogene protein c-fos (P01100) | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Neurologic And Neurobehavioral Disorder | wild-type p53 (P04637) | The p53 protein was expressed in arsenic trioxide-treated cells, however, the densitometric analysis did not show any significant differences (p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|