| Drug Name: | Apomorphine (58-00-4) |
|---|---|
| PubChem ID: | 6005 |
| SMILES: | CN1CCC2=CC=CC3=C2[C@H]1CC4=C3C(=C(C=C4)O)O |
| InchiKey: | VMWNQDUVQKEIOC-CYBMUJFWSA-N |
| Therapeutic Category: | Anti-Dyskinesia Agents, Antiparkinson Agents, Autonomic Agents, Central Nervous System Agents, Dopamine Agents, Dopamine Agonists, Emetics, Gastrointestinal Agents, Neurotransmitter Agents, Peripheral Nervous System Agents |
| Molecular Weight (dalton) | : | 267.328 |
| LogP | : | 2.8499 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 43.7 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Nitroglycerin (55-63-0) | Hypotension | Additive | Apomorphine alone cause postural hypotension, and this is potentially additive with the effects of vasoactive antihypertensives and nitrates | Cardiovascular safety of sublingual apomorphine in patients on stable doses of oral antihypertensive agents and nitrates |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Lesions | Proto-oncogene protein c-fos (P01100) | Repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions [ ADR Type 2 ] | Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions |
| Rotational Behavior | Proto-oncogene protein c-fos (P01100) | Repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions [ ADR Type 2 ] | Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category