| Drug Name: | Acenocoumarol (152-72-7) |
|---|---|
| PubChem ID: | 54676537 |
| SMILES: | CC(=O)CC(C1=CC=C(C=C1)[N+](=O)[O-])C2=C(C3=CC=CC=C3OC2=O)O |
| InchiKey: | VABCILAOYCMVPS-UHFFFAOYSA-N |
| Therapeutic Category: | Anticoagulants, Hematologic Agents |
| Molecular Weight (dalton) | : | 353.33 |
| LogP | : | 3.5178 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 110.65 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Amiodarone (1951-25-3) | Bleeding | Antagonistic | Amiodarone inhibits the metabolism of Acenocoumarol, probably because it,and/'or its metabolite desethylamiodarone, inhibit the cytochrome P450isoenzyme CYP2C9, CYP3A4 and CYP1A4 | Dangers of amiodarone and anticoagulant treatment (Pubmed ID 6788267) |
| Cefaclor (53994-73-3) | Anticoagulation | Additive | Cephalosporins with an N-methylthiotetrazole side-chain can, like the oral anticoagulants, act as vitamin K antagonists to reduce the production of some blood clotting factors. They can therefore cause bleeding on their own. | Influence of cephalosporin antibiotics on blood coagulation and platelet function |
| Cefonicid (61270-58-4) | Anticoagulation | Additive | cephalosporins with the N-methylthiotetrazole side-chain appear to increase the risk of bleeding, and might therefore interact | Life-threatening bleeding in a patient treated with cefonicid |
| Cefotiam (61622-34-2) | Anticoagulation | Additive | cephalosporins with the N-methylthiotetrazole side-chain appear to increase the risk of bleeding, and might therefore interact | Influence of cephalosporin antibiotics on blood coagulation and platelet function |
| Clarithromycin (81103-11-9) | Bleeding | Antagonistic | Not understood | Interaction between clarithromycin and oral anticoagulants |
| Fosinopril (98048-97-6) | Melaena | Additive | Unknown | Plausible pharmacologic interaction between fosinopril and acenocoumarol |
| Nalidixic Acid (389-08-2) | Bleeding | Antagonistic | Uncertain. It is not clear what factors might have been responsible in those cases where the effects of the anticoagulants were increased. nalidixic acid can displace acenocoumarol from its binding sites on human plasma albumin, but this mechanism on its own is almost certainly not the full explanation | Nicoumalone and nalidixic acid interaction |
| Oxymetholone (434-07-1) | Bleeding | Antagonistic | Not understood | Decreased anticoagulant tolerance with oxymetholone |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category