| Drug Name: | Gemcitabine (95058-81-4) |
|---|---|
| PubChem ID: | 60750 |
| SMILES: | C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F |
| InchiKey: | SDUQYLNIPVEERB-QPPQHZFASA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 263.2 |
| LogP | : | -1.2886 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 7 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 110.6 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Tumor Response | Apoptosis regulator Bcl-2 (P10415) | Eleven (32%) and 14 (41%) advanced non-small-cell lung cancer (NSCLC) cases were found positive for DR5 and Bcl-2@ respectively@The response rate was significantly higher in patients with DR5 expression@therefore@Death receptor 5 and Bcl-2 protein expression is as predictors of tumor response. [ ADR Type 2 ] | Death receptor 5 and Bcl-2 protein expression as predictors of tumor response to gemcitabine and cisplatin in patients with advanced non-small-cell lung cancer |
| Tumor Response | Tumor necrosis factor receptor superfamily member 10B (O14763) | Eleven (32%) and 14 (41%) advanced non-small-cell lung cancer (NSCLC) cases were found positive for DR5 and Bcl-2, respectively,The response rate was significantly higher in patients with DR5 expression,therefore,Death receptor 5 and Bcl-2 protein expression is as predictors of tumor response. [ ADR Type 2 ] | Death receptor 5 and Bcl-2 protein expression as predictors of tumor response to gemcitabine and cisplatin in patients with advanced non-small-cell lung cancer |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category