InAADR

Drug Information

Drug Name: Fluvastatin (93957-54-1)
PubChem ID: 6347538
SMILES: CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
InchiKey: FJLGEFLZQAZZCD-VVZAMHAXSA-N
Therapeutic Category: Anticholesteremic Agents, Antilipemic Agents, Antimetabolites, Enzyme Inhibitors, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypolipidemic Agents, Lipid Regulating Agents

Computed Drug Properties

Molecular Weight (dalton): 411.473
LogP: 4.6281
Ring Count: 3
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 82.69

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Atherosclerosis Angiotensin-converting enzyme precursor (P12821) Lipid changes (e.g.@ reductions in low-density lipoprotein cholesterol and apolipoprotein B);progression or regression of coronary atherosclerosis [ ADR Type 1 ] Insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme and myocardial infarction
Atherosclerosis Apolipoprotein E (P02649) Progression of atherosclerosis, ischemic cardiovascular events [ ADR Type 2 ] Faergeman O The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction : a substudy of the
Atherosclerosis Liver carboxylesterase 1 (P23141) Progression of atherosclerosis [ ADR Type 2 ] Polymorphism of the cholesteryl ester transfer protein gene
Ischemia Apolipoprotein E (P02649) Progression of atherosclerosis, ischemic cardiovascular events [ ADR Type 2 ] Faergeman O The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction : a substudy of the
Risk Of Repeated Angioplasty Stromelysin-1 (P08254) Reduction in cardiovascular events by pravastatin(death@ myocardial infarction@stroke@ angina@ and others); reduction in risk of repeated angioplasty. [ ADR Type 2 ] Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abnormal Ecg MetaADEDB
Abnormal Gait MetaADEDB
Abnormal Lfts MetaADEDB
Accidental Injury ADReCS
Acetonaemia MetaADEDB
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acidosis MetaADEDB
Actinic Keratosis MetaADEDB
Acute Coronary Syndrome MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Pulmonary Oedema MetaADEDB
Acute Respiratory Distress Syndrome MetaADEDB
Acute Sinusitis MetaADEDB
Adenocarcinoma MetaADEDB
Adenoma MetaADEDB
Adh Inappropriate MetaADEDB
Adrenal Neoplasm MetaADEDB
Affective Disorder MetaADEDB
Afib MetaADEDB
Agitated MetaADEDB
Agraphia MetaADEDB
Alanine Aminotransferase Increased MetaADEDB
Aldolase Increased MetaADEDB
Allergic Dermatitis MetaADEDB
Allergy ADReCS
Alopecia ADReCS
Alveoloplasty MetaADEDB
Amnesia ADReCS
Amyloidosis MetaADEDB
Anaemia ADReCS
Anaesthesia MetaADEDB
Anal Fissure MetaADEDB
Anal Polyp MetaADEDB
Anaphylactic Reaction ADReCS
Anaphylactic Shock ADReCS
Angioedema ADReCS
Anhedonia MetaADEDB
Ankle Fracture MetaADEDB
Anorexia ADReCS
Anti-Insulin Antibody MetaADEDB
Antinuclear Antibody Positive ADReCS
Anxiety ADReCS
Aortic Valve Sclerosis MetaADEDB
Apathy MetaADEDB
Apical Granuloma MetaADEDB
Appendicitis MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthralgia ADReCS
Arthritis ADReCS
Arthritis Rheumatoid MetaADEDB
Arthropathy ADReCS
Aseptic Necrosis Bone MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Asthenia ADReCS
Asthma MetaADEDB
Atrial Fibrillation ADReCS
Atrophy MetaADEDB
Aura MetaADEDB
Back Ache MetaADEDB
Back Pain ADReCS
Band Neutrophil Percentage Decreased MetaADEDB
Band Neutrophil Percentage Increased MetaADEDB
Basedow Disease MetaADEDB
Bence Jones Protein Urine MetaADEDB
Biopsy Muscle Abnormal MetaADEDB
Bipolar Disorder MetaADEDB
Bladder Cancer MetaADEDB
Blast Cell Count Increased MetaADEDB
Bleeding Gums MetaADEDB
Blindness ADReCS
Blood Albumin Decreased MetaADEDB
Blood Alkaline Phosphatase Increased ADReCS
Blood Beta-D-Glucan Increased MetaADEDB
Blood Bilirubin Increased ADReCS
Blood Chloride Decreased MetaADEDB
Blood Cholesterol MetaADEDB
Blood Creatine Phosphokinase Decreased MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Glucose Decreased MetaADEDB
Blood Immunoglobulin A Increased MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Ph Decreased MetaADEDB
Blood Pressure Systolic Increased MetaADEDB
Blood Sodium MetaADEDB
Blood Urine Present MetaADEDB
Body Temperature Increased ADReCS
Bone Disorder MetaADEDB
Bone Fracture MetaADEDB
Bone Lesion MetaADEDB
Bone Neoplasm Malignant MetaADEDB
Bone Pain MetaADEDB
Borderline Personality Disorder MetaADEDB
Bradycardia MetaADEDB
Brain Compression MetaADEDB
Brain Herniation MetaADEDB
Brain Scan Abnormal MetaADEDB
Breast Microcalcification MetaADEDB
Breast Neoplasm MetaADEDB
Bronchitis MetaADEDB
Bronchitis ADReCS
Bronchopneumonia MetaADEDB
Burning Sensation MetaADEDB
C-Reactive Protein Increased MetaADEDB
Candidiasis Of Mouth MetaADEDB
Carcinoma Of Prostate MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Disease MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure MetaADEDB
Cardiac Flutter MetaADEDB
Cardiogenic Shock MetaADEDB
Carotid Artery Disease MetaADEDB
Carotid Artery Stenosis MetaADEDB
Carpal Tunnel MetaADEDB
Cataract ADReCS
Cataract Nuclear MetaADEDB
Cataract Operation MetaADEDB
Cell Death MetaADEDB
Cellulitis MetaADEDB
Cerebellar Infarction MetaADEDB
Cerebral Atrophy MetaADEDB
Cerebral Haemorrhage MetaADEDB
Cerebral Infarct MetaADEDB
Cervical Vertebral Fracture MetaADEDB
Chest Pain ADReCS
Chest X-Ray Abnormal MetaADEDB
Chills ADReCS
Chronic Kidney Disease MetaADEDB
Chronic Sinusitis MetaADEDB
Clavicle Fracture MetaADEDB
Coccydynia MetaADEDB
Cognitive Disorder ADReCS
Cold Extremities MetaADEDB
Colitis Pseudomembranous MetaADEDB
Compression Fracture MetaADEDB
Computerised Tomogram MetaADEDB
Confabulation MetaADEDB
Confusional State ADReCS
Conjunctivitis ADReCS
Constipation ADReCS
Coronary Artery Insufficiency MetaADEDB
Coronary Artery Occlusion MetaADEDB
Cough ADReCS
Coughing Blood MetaADEDB
Cramp Muscle SIDER
Cranial Nerve Disorder ADReCS
Cytomegalovirus Viraemia MetaADEDB
Decreased Appetite ADReCS
Decreased Lacrimation MetaADEDB
Deep Vein Thromboses MetaADEDB
Deglutition Disorder MetaADEDB
Dehydration MetaADEDB
Demyelination MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Dermatomyositis MetaADEDB
Device Malfunction MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetic Complication MetaADEDB
Diabetic Neuropathy MetaADEDB
Diabetic Retinopathy MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Difficulty In Walking MetaADEDB
Dilatation Atrial MetaADEDB
Diplopia MetaADEDB
Discomfort ADReCS
Disease Progression MetaADEDB
Diverticulitis MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drug Intolerance MetaADEDB
Drug Rash With Eosinophilia And Systemic Symptoms ADReCS
Drug Withdrawal Headache MetaADEDB
Dry Skin ADReCS
Dysaesthesia ADReCS
Dysgeusia ADReCS
Dysmenorrhea MetaADEDB
Dyspepsia ADReCS
Dysphonia MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea ADReCS
Dyspnoea Exertional ADReCS
Ecg Signs Of Ventricular Hypertrophy MetaADEDB
Eczema ADReCS
Electrocardiogram Repolarisation Abnormality MetaADEDB
Electromechanical Dissociation MetaADEDB
Emesis MetaADEDB
Emphysema MetaADEDB
Encephalomalacia MetaADEDB
Endoscopic Retrograde Cholangiopancreatography MetaADEDB
Enterocolitis Infectious MetaADEDB
Eosinophilia ADReCS
Epidermal Necrosis ADReCS
Erectile Dysfunction ADReCS
Eructation ADReCS
Erythema ADReCS
Erythema Migrans MetaADEDB
Erythema Multiforme ADReCS
Excess Potassium MetaADEDB
Excoriation MetaADEDB
Exploratory Operation MetaADEDB
Extraocular Muscle Disorder ADReCS
Extremity Pain MetaADEDB
Face Injury MetaADEDB
Face Oedema ADReCS
Facial Neuralgia MetaADEDB
Facial Paresis ADReCS
Faeces Discoloured MetaADEDB
Fascitis Plantar MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue ADReCS
Fatty Liver MetaADEDB
Feeling Abnormal ADReCS
Femur Fracture MetaADEDB
Flatulence ADReCS
Fluid Overload MetaADEDB
Flushing ADReCS
Focal Glomerulosclerosis MetaADEDB
Foot Fracture MetaADEDB
Gambling MetaADEDB
Gamma-Glutamyltransferase Increased ADReCS
Gastric Disorder ADReCS
Gastric Hyperplasia MetaADEDB
Gastric Ulcer Perforated MetaADEDB
Gastric Ulcer Surgery MetaADEDB
Gastritis ADReCS
Gastroenteritis Clostridial MetaADEDB
Gastrointestinal Disorder MetaADEDB
Gastrointestinal Pain ADReCS
General Physical Health Deterioration MetaADEDB
Gingival Erythema MetaADEDB
Gliosis MetaADEDB
Globulinuria MetaADEDB
Glossoptosis MetaADEDB
Granulocyte Count Decreased MetaADEDB
Gynaecomastia ADReCS
Haemodialysis MetaADEDB
Haemolytic Anaemia ADReCS
Haemorrhoids MetaADEDB
Hair Disorder ADReCS
Hay Fever MetaADEDB
Headache ADReCS
Heart Attack MetaADEDB
Heartburn ADReCS
Hepatic Cirrhosis ADReCS
Hepatic Failure ADReCS
Hepatic Function Abnormal MetaADEDB
Hepatic Necrosis ADReCS
Hepatic Neoplasm Malignant ADReCS
Hepatic Steatosis ADReCS
Hepatitis ADReCS
Hepatitis B Positive MetaADEDB
Hepatitis Chronic Active ADReCS
Hepatitis Fulminant ADReCS
Hepatotoxicity MetaADEDB
Herpes Zoster MetaADEDB
High Blood Pressure MetaADEDB
Hot Flush ADReCS
Hydrocephalus MetaADEDB
Hyperhidrosis ADReCS
Hyperreflexia MetaADEDB
Hypersensitive Syndrome SIDER
Hypersensitivity ADReCS
Hypertension ADReCS
Hypoaesthesia ADReCS
Hypovolaemia MetaADEDB
Ichthyosis ADReCS
Ichthyosis Acquired ADReCS
Iiird Nerve Paralysis ADReCS
Ileal Ulcer MetaADEDB
Ill-Defined Disorder ADReCS
Impaired Driving Ability MetaADEDB
Impaired Fasting Glucose MetaADEDB
Impaired Healing MetaADEDB
Incisional Hernia MetaADEDB
Increased White Blood Cell Count MetaADEDB
Infected Skin Ulcer MetaADEDB
Infection ADReCS
Influenza ADReCS
Influenza Like Illness ADReCS
Infusion Site Mobility Decreased MetaADEDB
Injury ADReCS
Insomnia ADReCS
Intermittent Claudication ADReCS
International Normalised Ratio Decreased MetaADEDB
Intervertebral Disc Degeneration MetaADEDB
Intervertebral Disc Disorder MetaADEDB
Intestinal Hypomotility MetaADEDB
Intravascular Haemolysis MetaADEDB
Intussusception MetaADEDB
Iron Deficiency Anaemia MetaADEDB
Jaundice ADReCS
Jaundice Cholestatic ADReCS
Jaw Disorder MetaADEDB
Jaw Fracture MetaADEDB
Jaw Operation MetaADEDB
Joint Contracture MetaADEDB
Joint Range Of Motion Decreased MetaADEDB
Jugular Vein Thrombosis MetaADEDB
Kyphosis MetaADEDB
Lacunar Infarction MetaADEDB
Leg Amputation MetaADEDB
Leg Pain ADReCS
Lens Disorder ADReCS
Lenticular Opacities ADReCS
Leucopenia MetaADEDB
Leukocyturia MetaADEDB
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Libido Decreased ADReCS
Limb Discomfort MetaADEDB
Limb Operation MetaADEDB
Lip Erosion MetaADEDB
Liver Carcinoma SIDER
Liver Fatty SIDER
Localised Infection MetaADEDB
Loss Of Libido ADReCS
Lumbar Spinal Stenosis MetaADEDB
Lung Infection MetaADEDB
Lupus Erythematosus SIDER
Lupus-Like Syndrome ADReCS
Macular Oedema MetaADEDB
Malaise ADReCS
Memory Impairment ADReCS
Memory Loss SIDER
Meningitides MetaADEDB
Meningitis Viral MetaADEDB
Menopausal Symptoms ADReCS
Mental Disorder ADReCS
Middle Insomnia MetaADEDB
Miosis MetaADEDB
Mitral Valve Disease MetaADEDB
Mouth Breathing MetaADEDB
Mouth Pain MetaADEDB
Mucosal Dryness ADReCS
Mucosal Erosion MetaADEDB
Mucosal Inflammation MetaADEDB
Multiple Myeloma MetaADEDB
Muscle Fatigue MetaADEDB
Muscle Inflammation MetaADEDB
Muscle Spasms ADReCS
Muscle Tightness MetaADEDB
Muscle Weakness MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Discomfort ADReCS
Musculoskeletal Stiffness MetaADEDB
Myalgia ADReCS
Mycobacterium Tuberculosis Infection MetaADEDB
Mycosis Fungoides MetaADEDB
Myoglobin Blood Increased MetaADEDB
Myopathy ADReCS
Myopia MetaADEDB
Myositis ADReCS
Nail Disorder ADReCS
Nail Tinea MetaADEDB
Nasopharyngitis ADReCS
Nausea ADReCS
Necrolysis Epidermal SIDER
Necrosis ADReCS
Nephrogenic Fibrosing Dermopathy MetaADEDB
Nerve Paralysis SIDER
Neumonia MetaADEDB
Neuroleptic Malignant Syndrome MetaADEDB
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Nodule ADReCS
Non-Cardiac Chest Pain MetaADEDB
Non-Small Cell Lung Cancer MetaADEDB
Nuclear Magnetic Resonance Imaging Abnormal MetaADEDB
Oedema ADReCS
Oedema Mucosal MetaADEDB
Oedema Peripheral ADReCS
Ophthalmoplegia ADReCS
Optic Disc Edema MetaADEDB
Optic Ischaemic Neuropathy MetaADEDB
Optic Neuritis MetaADEDB
Oropharyngeal Pain MetaADEDB
Osteoarthritis ADReCS
Osteopenia MetaADEDB
Overdose MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain ADReCS
Pain In Extremity ADReCS
Palsies MetaADEDB
Pancreatitis ADReCS
Pancreatitis Acute ADReCS
Paraesthesia ADReCS
Paralysis ADReCS
Parathyroid Gland Enlargement MetaADEDB
Paresis ADReCS
Parotitis MetaADEDB
Periodontitis MetaADEDB
Peripheral Arterial Occlusive Disease MetaADEDB
Peripheral Nerve Palsy ADReCS
Peripheral Sensory Neuropathy ADReCS
Peritonitis MetaADEDB
Petechia MetaADEDB
Phantom Pain MetaADEDB
Pharyngitis ADReCS
Pharyngolaryngeal Pain MetaADEDB
Phlebitis MetaADEDB
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Pitting Oedema MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pleurodesis MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia Mycoplasmal MetaADEDB
Pneumothorax MetaADEDB
Polymyalgia SIDER
Polymyalgia Rheumatica ADReCS
Post Procedural Haematoma MetaADEDB
Productive Cough MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus ADReCS
Pruritus Generalised MetaADEDB
Pulmonary Alveolar Haemorrhage MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Hypertension MetaADEDB
Pulpitis Dental MetaADEDB
Pupillary Reflex Impaired MetaADEDB
Purpura ADReCS
Pustular Psoriasis MetaADEDB
Pyloric Stenosis MetaADEDB
Pyrexia ADReCS
Radical Prostatectomy MetaADEDB
Radicular Syndrome MetaADEDB
Rash ADReCS
Red Blood Cell Sedimentation Rate Increased ADReCS
Renal Artery Stent Placement MetaADEDB
Renal Failure ADReCS
Renal Failure Acute ADReCS
Reticulocyte Count Decreased MetaADEDB
Rhabdomyolysis ADReCS
Rhinitis ADReCS
Rib Fracture MetaADEDB
Road Traffic Accident MetaADEDB
Sclc MetaADEDB
Secondary Immunodeficiency MetaADEDB
Sensory Loss MetaADEDB
Septic Shock MetaADEDB
Sequestrectomy MetaADEDB
Sick Sinus Syndrome MetaADEDB
Sinus Bradycardia MetaADEDB
Sinusitis ADReCS
Sjogren Syndrome MetaADEDB
Skeletal Survey Abnormal MetaADEDB
Skin Desquamation MetaADEDB
Skin Discolouration ADReCS
Skin Induration MetaADEDB
Skin Tightness MetaADEDB
Sleep Apnea MetaADEDB
Speech Disorder MetaADEDB
Spinal Column Stenosis MetaADEDB
Spinal Compression Fracture MetaADEDB
Spinal Cord Compression MetaADEDB
Spinal Cord Oedema MetaADEDB
Spinal Fracture MetaADEDB
Spinal Laminectomy MetaADEDB
Spinal Myelogram MetaADEDB
Spinal Operation MetaADEDB
Spinal Osteoarthritis MetaADEDB
Spinning Sensation MetaADEDB
Spondylitis MetaADEDB
Steal Syndrome MetaADEDB
Stevens-Johnson Syndrome ADReCS
Stress Fracture MetaADEDB
Sweating SIDER
Syncope ADReCS
Synovial Cyst MetaADEDB
Systemic Lupus Erythematosus ADReCS
Systemic Lupus Erythematosus-Like Syndrome ADReCS
Tenderness ADReCS
Tenderness Muscle SIDER
Tendon Disorder MetaADEDB
Therapeutic Response Decreased MetaADEDB
Therapeutic Response Unexpected MetaADEDB
Thrombocytopenia ADReCS
Thyroid Disorder ADReCS
Thyroid Function Test Abnormal ADReCS
Tinea Pedis MetaADEDB
Tongue Discolouration ADReCS
Tongue Paralysis MetaADEDB
Tooth Disease MetaADEDB
Tooth Disorder ADReCS
Tooth Extraction MetaADEDB
Toxic Epidermal Necrolysis ADReCS
Tracheobronchitis MetaADEDB
Transaminases Increased ADReCS
Tremor ADReCS
Troponin I Increased MetaADEDB
Urinary Tract Infection ADReCS
Urticaria ADReCS
Vascular Purpura ADReCS
Vasculitis ADReCS
Vertebroplasty MetaADEDB
Vertigo ADReCS
Vestibular Disorder MetaADEDB
Viith Nerve Paralysis ADReCS
Visual Acuity Reduced ADReCS
Visual Impairment ADReCS
Vitamin A Deficiency MetaADEDB
Vomiting ADReCS
Walking Aid User MetaADEDB
Weakness SIDER
Weight Gain MetaADEDB
Wisdom Teeth Removal MetaADEDB
Wound Drainage MetaADEDB

InAADR: Drug-Protein-ADRs database